| Hepatobiliary transit times of gadoxetate disodium (Primovist(®)) for protocol optimization of comprehensive MR imaging of the biliary system-What is normal? | |
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MedLine Citation:
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PMID: 20347540 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to determine transit times for excretion of Gd-EOB-DTPA into different segments of the hepatobiliary system in patients with normal liver function. METHODS: This retrospective study was IRB approved with a waiver of consent granted. 61 patients (39 female, 22 male, mean age 52.5 years) with normal liver and renal function who underwent contrast enhanced hepatic MRI after injection of 10mLGd-EOB-DTPA at 1.5T and 3T were included. Two readers evaluated all delayed images (3-20min post contrast) for the presence of contrast agent in the intrahepatic bile ducts (IBD), the common bile duct (CBD), the gallbladder and the duodenum. A two-tailed, unpaired Student's t-test with p<0.05 deemed significant was used to determine whether transit times were affected by patient gender, age or body mass index. RESULTS: 20min after contrast initiation, Gd-EOB-DTPA could be detected in the IBD and the CBD in all patients (100%); gallbladder reflux was visible in 53 (86.9%), duodenal excretion in 40 patients (65.5%), respectively. Mean transit times for contrast appearance in the various segments were as follows: IBD 12min 13s; CBD 12min 27s; gallbladder 13min 32s. Transit times were not significantly affected by patient gender, age or BMI. CONCLUSION: Within 20min post contrast initiation, Gd-EOB-DTPA can be expected in the IBD and the CBD in patients with normal liver function. However, functional information about the sphincter Oddi complex can be ascertained only in about two thirds of these patients within this timeframe. |
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Authors:
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Kristina I Ringe; Daniela B Husarik; Rajan T Gupta; Daniel T Boll; Elmar M Merkle |
Publication Detail:
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Type: Journal Article Date: 2010-03-29 |
Journal Detail:
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Title: European journal of radiology Volume: 79 ISSN: 1872-7727 ISO Abbreviation: Eur J Radiol Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 201-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Duke University Medical Center, Department of Radiology, Box 3808, Durham, NC 27710, United States; Hannover Medical School, Department of Radiology, Carl-Neuberg Str. 1, 30625 Hannover, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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