| Hepatobiliary handling of iodine-125-Tyr3-octreotide and indium-111-DTPA-D-Phe1-octreotide by isolated perfused rat liver. | |
| | |
MedLine Citation:
|
PMID: 8229254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Radiolabeled bioactive peptides may show receptor-mediated binding to tumors, making them suitable for scintigraphic imaging. The liver is an important organ for peptide clearance. To gain insight into the uptake and intracellular processing of somatostatin analogs, we compared the hepatobiliary handling of 125I-Tyr3-octreotide and 111In-DTPA-D-Phe1-octreotide, which are successfully used to image somatostatin receptor-positive tumors in vivo in isolated recirculating perfused rat livers. Sixty minutes following administration of the radiolabeled peptides, perfusion medium and biliary radioactivity were analyzed. Radioiodinated Tyr3-octreotide was rapidly cleared by the liver and 60% of the dose was excreted intact into the bile after 60 min. In contrast, 111In-DTPA-D-Phe1-octreotide was not cleared by the liver; medium radioactivity levels remained about constant and only 2% of the dose was found in the bile. These results are in agreement with in vivo findings in rats and humans. We concluded that isolated rat liver perfusion is a good system to rapidly gain insight into the hepatic handling of radiopharmaceuticals. |
| | |
Authors:
|
M de Jong; W H Bakker; W A Breeman; M E van der Pluijm; P P Kooij; T J Visser; R Docter; E P Krenning |
Related Documents
:
|
10993764 - Comparison of blood-brain barrier permeability in mice and rats using in situ brain per... 3925794 - Effect of metabolic acidosis on proximal tubular total co2 absorption. 20504724 - Modulation of [(3)h]noradrenaline release by endothelin-1 in the rat tail artery. 2876824 - Ciliary beating frequency of frog palate and rat trachea explants under continuous perf... 11945454 - Studies on the half life time of rat liver transfer rna species. 7943314 - Downregulation of taurocholate transport by ileal bbm and liver blm in biliary-diverted... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 34 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1993 Nov |
Date Detail:
|
Created Date: 1993-11-29 Completed Date: 1993-11-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 2025-30 Citation Subset: IM |
Affiliation:
|
Department of Nuclear Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bile / metabolism* Liver / metabolism* Male Octreotide / analogs & derivatives*, pharmacokinetics Pentetic Acid / analogs & derivatives*, pharmacokinetics Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
142694-57-3/SDZ 215-811; 67-43-6/Pentetic Acid; 83150-76-9/Octreotide |
| Comments/Corrections | |
Comment In:
|
J Nucl Med. 1993 Nov;34(11):2030-1
[PMID:
7901352
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Principal axes and surface fitting methods for three-dimensional image registration.
Next Document: Chromatographic identification in serum of endogenously radioiodinated thyroid hormones after iodine...