Document Detail


Hepatobiliary excretion of dipyrrinone sulfonates in Mrp2-deficient (TR(-)) rats.
MedLine Citation:
PMID:  12161163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biliary excretion of the sodium salts of 8-(2-ethanesulfonic acid)-3-ethyl-2,7,9-trimethyl-1,10-dihydro-11H-dipyrrin-1-one (xanthosulfonic acid) and a fluorescent analogue (8-desethyl-N,N'-carbonyl-kryptopyrromethenone-8-sulfonic acid) was compared in Mrp2-deficient (TR(-)) and normal rats. Both organic anions were excreted rapidly in bile in Mrp2-deficient rats, but the biliary excretion of the fluorescent sulfonate was impaired relative to normal controls. The rat clearly has efficient Mrp2-independent mechanisms for biliary efflux of these anions that are not used by bilirubin or its mono- and diglucuronides.
Authors:
Antony F McDonagh; David A Lightner; Stefan E Boiadjiev; Justin O Brower; Wilma S Norona
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  12     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-05     Completed Date:  2003-07-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  2483-6     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, S-357, Box 0538, University of California, San Francisco, CA 94143-0538, USA. tonymcd@itsa.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Alkanesulfonates / administration & dosage,  metabolism,  pharmacokinetics*
Animals
Bile Acids and Salts
Biliary Tract / secretion*
Chromatography, High Pressure Liquid
Fluorescent Dyes / administration & dosage,  diagnostic use
Membrane Transport Proteins*
Multidrug Resistance-Associated Proteins / genetics,  physiology*
Rats
Rats, Mutant Strains
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DK26307/DK/NIDDK NIH HHS; GM36633/GM/NIGMS NIH HHS; HD17779/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Alkanesulfonates; 0/Bile Acids and Salts; 0/Fluorescent Dyes; 0/Membrane Transport Proteins; 0/Multidrug Resistance-Associated Proteins; 0/multidrug resistance-associated protein 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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