Document Detail


Hepatitis A vaccine associated with autoimmune hepatitis.
MedLine Citation:
PMID:  17465509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To describe a case of probable relapsing autoimmune hepatitis associated with vaccination against hepatitis A virus (HAV). A case report and review of literature were written concerning autoimmune hepatitis in association with hepatitis A and other hepatotropic viruses. Soon after the administration of formalin-inactivated hepatitis A vaccine, a man who had recently recovered from an uncharacterized but self-limiting hepatitic illness, experienced a severe deterioration (AST 1687 U/L, INR 1.4). Anti-nuclear antibodies were detectable, and liver biopsy was compatible with autoimmune hepatitis. The observation supports the role of HAV as a trigger of autoimmune hepatitis. Studies in helper T-cell activity and antibody expression against hepatic proteins in the context of hepatitis A infection are summarized, and the concept of molecular mimicry with regard to other forms of viral hepatitis and autoimmunity is briefly explored.
Authors:
P-A Berry; G Smith-Laing
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  13     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-09-25     Revised Date:  2014-09-07    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  2238-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Hepatitis A Vaccines / adverse effects*
Hepatitis A virus / physiology
Hepatitis, Autoimmune / diagnosis*,  etiology*
Humans
Liver / immunology,  pathology,  virology
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Hepatitis A Vaccines
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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