Document Detail

Hepatitis A vaccination in healthcare personnel.
MedLine Citation:
PMID:  22481450     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Despite effective vaccine available, hepatitis A remains a significant cause of morbidity and mortality worldwide including acute liver failure, transplantation and death. Vaccination rates for hepatitis A in the general population are low. Rates of hepatitis A vaccination in healthcare personnel (HCP) are unknown. We studied vaccination rate to hepatitis A in a cohort of HCP at a large US academic center.
MATERIAL AND METHODS: An anonymous survey was circulated between 499 HCP at-risk of hepatitis A exposure at our Institution. Results were corrected for non-response rate and compared with the general US population using the 2007 CDC-National Immunization Survey. Rate of hepatitis A vaccination was compared with Institutional rate of vaccination for the Influenza 2009-2010 season.
RESULTS: Rate of vaccination for hepatitis A in HCP was 28.8% (response rate 41.4%; 207/499), with 58.9% having completed the full series and 24.7% being tested for post-vaccination immunity. Acceptance rate among non-vaccinated subjects was 70.7%. HCP hepatitis A vaccination rate was statistically greater than the national general population (28.8 vs. 12.1%, p ≤ 0.031). A statistically significant greater vaccination rate was found among US born responders vs. foreign-born HCP (34.3 vs. 19.3%, p = 0.0324). Vaccination for hepatitis A was statistically inferior to that of Influenza (28.8 vs. 90%; P = 0.01).
CONCLUSIONS: HCP have statistically higher vaccination rate for hepatitis A than the general population, but overall protection remains suboptimal with vaccination rate below those for mandatory vaccines. Further studies to determine whether hepatitis A vaccine is cost-effective in HCP are recommended.
Praveen Guturu; Luca Cicalese; Andrea Duchini
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of hepatology     Volume:  11     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2012 May-Jun
Date Detail:
Created Date:  2012-04-06     Completed Date:  2012-08-23     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  326-9     Citation Subset:  IM    
Division of Gastroenterology, Department of Medicine, University of Texas Medical Branch, Galveston, 77555, USA.
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MeSH Terms
Cohort Studies
Cross-Sectional Studies
Health Personnel*
Health Surveys
Hepatitis A / epidemiology,  immunology,  prevention & control*
Hepatitis A Vaccines / therapeutic use*
Hepatitis A virus / immunology*
Retrospective Studies
Risk Factors
United States / epidemiology
Reg. No./Substance:
0/Hepatitis A Vaccines

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