| Hepatitis in fatal infectious mononucleosis. | |
| | |
MedLine Citation:
|
PMID: 3678738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A detailed clinicopathologic analysis of 30 patients with sporadic fatal infectious mononucleosis and 31 males with fatal infectious mononucleosis and the X-linked lymphoproliferative syndrome was performed to determine the extent of hepatic dysfunction in these cases. At death, the median age of patients with sporadic infectious mononucleosis was 10.7 yr vs. 2.4 yr for X-linked lymphoproliferative syndrome. The median survival time was 8 wk for sporadic infectious mononucleosis and only 4 wk for X-linked lymphoproliferative syndrome. The male to female ratio was 3:2 in sporadic infectious mononucleosis; all patients with X-linked lymphoproliferative syndrome were males. Fever, sore throat, lymphadenopathy, hepatomegaly, and splenomegaly were prominent findings. Hepatic dysfunction was uniformly present and caused death in 13 of 30 sporadic infectious mononucleosis cases and 18 of 31 X-linked lymphoproliferative syndrome cases. Diagnosis of infectious mononucleosis was confirmed by heterophile antibody titers or Monospot, Epstein-Barr virus antibody studies, viral culture, molecular hybridization studies, clinical and histologic findings, and pedigree analysis. |
| | |
Authors:
|
R S Markin; J Linder; K Zuerlein; E Mroczek; H L Grierson; B Brichacek; D T Purtilo |
Related Documents
:
|
22309948 - First description of unilateral lung agenesis and anomalous pulmonary venous connection... 9608338 - Papular acrodermatitis of childhood related to poxvirus and parvovirus b19 infection. 832438 - "alice in wonderland" syndrome as a presenting symptom of infectious mononucleosis in c... 21706168 - A novel cutaneous vasculitis syndrome induced by levamisole-contaminated cocaine. 7986298 - Self-mutilation in a patient with mucolipidosis iii. 11051628 - Case report: one-and-a-half-syndrome and tuberculosis of the pons in a patient with aids. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Gastroenterology Volume: 93 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1987 Dec |
Date Detail:
|
Created Date: 1987-12-28 Completed Date: 1987-12-28 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1210-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pathology, University of Nebraska Medical Center, Omaha 68105. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Child Child, Preschool Female Hepatitis / etiology*, pathology Humans Infectious Mononucleosis / complications*, pathology Liver / pathology Lymphoproliferative Disorders / complications, genetics Male Syndrome X Chromosome |
| Grant Support | |
ID/Acronym/Agency:
|
CA30196/CA/NCI NIH HHS; CA36727/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intracellular transport and processing of secretory component in cultured rat hepatocytes.
Next Document: Hepatitis B virus deoxyribonucleic acid in serum during hepatitis B e antigen clearance in corticost...