Document Detail


Hepatitis c and cirrhotic liver disease in the Nile delta of Egypt: a community-based study.
MedLine Citation:
PMID:  11442209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Residents of Egypt's Nile river delta have among the world's highest seroprevalence of hepatitis C virus (HCV) infection. To assess the impact of HCV on chronic liver disease, we studied the association between HCV, other hepatitis viruses, and cirrhotic liver disease in a cross-sectional, community-based survey of 801 persons aged > or = 10 years living in a semi-urban, Nile delta village. Residents were systematically sampled using questionnaires, physical examination, abdominal ultrasonography and serologically for antibodies to HCV (confirmed by a third-generation immunoblot assay) and to hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis E virus (HEV). The seroprevalence of HCV increased with age from 19% in persons 10-19 years old to about 60% in persons 30 years and older. Although no practices that might facilitate HCV transmission were discovered, the seroprevalence of HCV was significantly associated with remote (> 1 year) histories of schistosomiasis. Sonographic evidence of cirrhosis was present in 3% (95% CI: 1%, 4%) of the population (0.7% of persons under 30 years of age and in 5% of older persons), and was significantly associated with HCV seroreactivity. Our findings are consistent with the hypothesis that past mass parenteral chemotherapy campaigns for schistosomiasis facilitated HCV transmission, and that HCV may be a major cause of the high prevalence of liver cirrhosis in this Nile village.
Authors:
M A Darwish; R Faris; N Darwish; A Shouman; M Gadallah; M S El-Sharkawy; R Edelman; K Grumbach; M R Rao; J D Clemens
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  64     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-07-09     Completed Date:  2001-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  AIM; IM    
Affiliation:
Ain Shams University School of Medicine, Cairo, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Child
Cross-Sectional Studies
Egypt / epidemiology
Female
Hepacivirus / immunology,  isolation & purification*
Hepatitis Antibodies / blood*
Hepatitis C / complications,  epidemiology*,  ultrasonography
Humans
Immunoblotting
Liver Cirrhosis / epidemiology*,  etiology,  ultrasonography
Male
Middle Aged
Physical Examination
Questionnaires
Seroepidemiologic Studies
Chemical
Reg. No./Substance:
0/Hepatitis Antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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