Document Detail

Hepatitis associated with micafungin use in a preterm infant.
MedLine Citation:
PMID:  19325554     Owner:  NLM     Status:  MEDLINE    
Micafungin is an echinocandin-class antifungal agent licensed for treatment of invasive disease in adults. The optimal dosing regimens have not been established for infants. We describe a premature infant who developed hepatitis and cholestasis during micafungin therapy initiated for protracted candidemia. Practitioners should be aware of this potential adverse effect if using micafungin in young patients.
K Y King; M S Edwards; B M Word
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  29     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-27     Completed Date:  2009-07-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-2     Citation Subset:  IM    
Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA.
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MeSH Terms
AIDS-Related Opportunistic Infections / drug therapy*
Alanine Transaminase / blood
Amphotericin B / administration & dosage,  adverse effects
Antifungal Agents / administration & dosage,  adverse effects*
Aspartate Aminotransferases / blood
Candidiasis / drug therapy*
Cholestasis / chemically induced,  diagnosis
Dose-Response Relationship, Drug
Drug Therapy, Combination
Drug-Induced Liver Injury / diagnosis,  etiology*
Echinocandins / administration & dosage,  adverse effects*
Fungemia / drug therapy*
Infant, Newborn
Infant, Premature, Diseases / drug therapy*
Lipopeptides / administration & dosage,  adverse effects*
Liver Function Tests
Reg. No./Substance:
0/Antifungal Agents; 0/Echinocandins; 0/Lipopeptides; 0/micafungin; 1397-89-3/Amphotericin B; EC Aminotransferases; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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