Document Detail

Hepatitis A among persons with hemophilia who received clotting factor concentrate--United States, September-December 1995.
MedLine Citation:
PMID:  8531917     Owner:  NLM     Status:  MEDLINE    
Hepatitis A outbreaks associated with receipt of clotting factor concentrate previously have been recognized in Europe but not in the United States (1-5). During September-November 1995, three cases of hepatitis A in recipients of Alphanate factor VIII concentrate (Alpha Therapeutic Corporation, Los Angeles, California) from lot number AP5014A were reported to CDC. On December 8, the manufacturer voluntarily withdrew Alphanate lot number AP5014A from the market. In addition, one case of hepatitis A in a recipient of AlphaNine S-D factor IX concentrate (Alpha Therapeutic Corporation) has been reported and is under investigation. On January 11, 1996, the manufacturer voluntarily withheld four lots of AlphaNine S-D from further distribution as a precautionary measure. This report describes these four cases, summarizes the status of the investigation of the cases, and provides guidelines for testing and reporting of patients who received these products.
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  MMWR. Morbidity and mortality weekly report     Volume:  45     ISSN:  0149-2195     ISO Abbreviation:  MMWR Morb. Mortal. Wkly. Rep.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-01     Completed Date:  1996-02-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7802429     Medline TA:  MMWR Morb Mortal Wkly Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  29-32     Citation Subset:  IM    
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MeSH Terms
Drug Contamination*
Factor IX / adverse effects,  therapeutic use
Factor VIII / adverse effects,  therapeutic use*
Hemophilia A / drug therapy*
Hepatitis A / epidemiology,  transmission*
United States / epidemiology
von Willebrand Diseases / drug therapy*
Reg. No./Substance:
9001-27-8/Factor VIII; 9001-28-9/Factor IX

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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