Document Detail

Hepatitis C virus types 7, 8 and 9 should be classified as type 6 subtypes.
MedLine Citation:
PMID:  8773919     Owner:  NLM     Status:  MEDLINE    
Tokita et al. reported the identification of hepatitis C virus type 7, 8 and 9 in Southeast Asia, based on the unweighed pair-group method with the arithmetic mean, a method that may not be appropriate when the nucleotide substitution rate is not constant over time. To determine more accurately the relationship of these proposed types 7, 8, and 9 with other types, a more appropriate approach, the neighbor-joining method, was applied to re-evaluate the phylogenetic relationship. A total of 660 HCV sequences, including the reported sequences, were collected from DNA databases. For every region, the nucleotide substitution rate was estimated by the 6-parameter method, and phylogenetic trees were constructed using the neighbor-joining method. The results of this analysis indicate that the newly proposed HCV types 7, 8 and 9 should be classified as type 6 subtypes. HCV type 6 appears to be diversified.
M Mizokami; T Gojobori; K Ohba; K Ikeo; X M Ge; T Ohno; E Orito; J Y Lau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hepatology     Volume:  24     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-22     Completed Date:  1996-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  622-4     Citation Subset:  IM; S    
Second Department of Internal Medicine, Nagoya City University, Japan.
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MeSH Terms
Evolution, Chemical
Hepacivirus / classification*
Nucleotides / chemistry*
Reg. No./Substance:

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