| Hepatitis C virus kinetics during the first phase of pegylated interferon-alpha-2b with ribavirin therapy in patients with living donor liver transplantation. | |
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MedLine Citation:
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PMID: 19624776 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aim: To identify the problems of pegylated interferon (PEG IFN) with ribavirin therapy against hepatitis C virus (HCV) reinfection in living donor liver transplantation (LDLT) patients. HCV kinetics during the PEG IFN with ribavirin therapy were analyzed in LDLT patients, as well as in chronic hepatitis C (CHC) patients. Methods: The study included 80 consecutive HCV infected patients undergoing PEG IFN with ribavirin therapy (64 CHC and 16 LDLT patients) who attended the Nagasaki University Hospital for an initial visit between January 2005 and December 2007. Results: The sustained viral response (VR) rate of the CHC group (80%) was superior to the LDLT group (22%). The viral disappearance rate of the CHC group was also superior to the LDLT group, regardless of the HCV serotype. The HCV core antigen (cAg) titer under treatment in the LDLT group was more than that of the CHC group from day 0 to week 12. The HCV cAg decrease rate of the LDLT group on the first day of treatment was less than that of the CHC group. Conclusion: The HCV infection of a transplanted liver is more refractory to treatment than a non-transplanted liver. The low reduction HCV cAg rate on day 1 is one of the problems of the combination therapy. |
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Authors:
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Tatsuki Ichikawa; Kazuhiko Nakao; Hisamitsu Miyaaki; Susumu Eguchi; Mitsuhisa Takatsuki; Masumi Fujimito; Motohisa Akiyama; Satoshi Miuma; Eisuke Ozawa; Hidetaka Shibata; Shigeyuki Takeshita; Takashi Kanematsu; Katsumi Eguchi |
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Publication Detail:
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Type: Journal Article Date: 2009-07-13 |
Journal Detail:
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Title: Hepatology research : the official journal of the Japan Society of Hepatology Volume: 39 ISSN: 1386-6346 ISO Abbreviation: Hepatol. Res. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9711801 Medline TA: Hepatol Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 856-64 Citation Subset: - |
Affiliation:
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The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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