Document Detail

Hepatitis C virus infection in the elderly. Epidemiology, prophylaxis and optimal treatment.
MedLine Citation:
PMID:  9342559     Owner:  NLM     Status:  MEDLINE    
Chronic infection with the hepatitis C virus (HCV) occurs throughout the world and appears to be the main cause of hepatocellular carcinoma. Studies have shown that, in areas of high endemicity, the prevalence of HCV infection is low in children but high in people aged > 60 years. Medical interventions were found to play an important role in the spread of HCV infection, because elderly patients became infected via contaminated blood transfusions or when contaminated syringes and needles were used. Maternal and sexual transmission do not appear to be the main routes of HCV infection. Interferon treatment eliminates HCV in 20 to 30% of patients with chronic HCV infection. The response to interferon therapy is usually complete in 70 to 80% of people with low levels of HCV RNA, HCV of genotype 2 and young women, but poor in elderly patients. Because liver disease can be severe in elderly patients, more effective therapies are clearly needed.
J Hayashi; S Kashiwagi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs & aging     Volume:  11     ISSN:  1170-229X     ISO Abbreviation:  Drugs Aging     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-03     Completed Date:  1997-12-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9102074     Medline TA:  Drugs Aging     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  296-308     Citation Subset:  IM    
Department of General Medicine, Kyushu University Hospital, Fukuoka, Japan.
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MeSH Terms
Biological Markers
Chronic Disease
Hepatitis C* / drug therapy,  epidemiology,  genetics,  immunology,  prevention & control
Hepatitis C Antibodies / analysis
Japan / epidemiology
RNA, Viral
Reg. No./Substance:
0/Biological Markers; 0/Hepatitis C Antibodies; 0/RNA, Viral

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