Document Detail

Hepatitis C virus infection in 'primary' Sjögren's syndrome: prevalence and clinical significance in a series of 90 patients.
MedLine Citation:
PMID:  9135219     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the prevalence and clinical significance of hepatitis C virus (HCV) infection in a large cohort of patients with "primary' Sjögren's syndrome (SS). METHODS: 90 consecutive patients (83 female and seven male) were included, with a mean age of 62 years (range 31-80) who prospectively visited our unit. All patients fulfilled the European Community criteria for SS and underwent a complete history, physical examination, as well as biochemical and immunological evaluation for liver disease. Serum from all patients was tested for antibodies to HCV by third generation enzyme linked immunoassay and positivity was confirmed by polymerase chain reaction. RESULTS: Antibodies to HCV were present in 13 (14%) patients with 'primary' SS. When compared with patients without HCV infection, patients with HCV infection presented a higher prevalence of hepatic involvement, (100% v 8%, p < 0.05). Transcutaneous liver biopsy was performed in five patients with HCV infection, and specimens obtained showed in all cases a chronic active hepatitis with varying degrees of portal inflammation. CONCLUSION: HCV infection is frequent in patients with "primary' SS and liver involvement is presented in all these patients. The possible pathogenic role of HCV infection in these patients is still unclear.
M García-Carrasco; M Ramos; R Cervera; J Font; J Vidal; F J Muñoz; C Miret; G Espinosa; M Ingelmo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  56     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-05-19     Completed Date:  1997-05-19     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  173-5     Citation Subset:  IM    
Systemic Autoimmune Diseases Unit, Hospital Clínic, Barcelona, Catalonia, Spain.
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MeSH Terms
Aged, 80 and over
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Hepatitis C / complications,  epidemiology*
Hepatitis C Antibodies / blood
Hepatitis, Chronic / complications,  epidemiology*
Liver / virology
Middle Aged
Polymerase Chain Reaction
Sjogren's Syndrome / epidemiology*,  virology
Spain / epidemiology
Reg. No./Substance:
0/Hepatitis C Antibodies

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