| Hepatitis C virus in Pakistan: a systematic review of prevalence, genotypes and risk factors. | |
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MedLine Citation:
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PMID: 19960560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In Pakistan more than 10 million people are living with Hepatitis C virus (HCV), with high morbidity and mortality. This article reviews the prevalence, genotypes and factors associated with HCV infection in the Pakistani population. A literature search was performed by using the keywords; HCV prevalence, genotypes and risk factors in a Pakistani population, in Pubmed, PakMediNet and Google scholar. Ninety-one different studies dating from 1994 to May 2009 were included in this study, and weighted mean and standard error of each population group was calculated. Percentage prevalence of HCV was 4.95% +/- 0.53% in the general adult population, 1.72% +/- 0.24% in the pediatric population and 3.64% +/- 0.31% in a young population applying for recruitment, whereas a very high 57% +/- 17.7% prevalence was observed in injecting drug users and 48.67% +/- 1.75% in a multi-transfused population. Most prevalent genotype of HCV was 3a. HCV prevalence was moderate in the general population but very high in injecting drug users and multi-transfused populations. This data suggests that the major contributing factors towards increased HCV prevalence include unchecked blood transfusions and reuse of injection syringes. Awareness programs are required to decrease the future burden of HCV in the Pakistani population. |
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Authors:
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Yasir Waheed; Talha Shafi; Sher Zaman Safi; Ishtiaq Qadri |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 15 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-04 Completed Date: 2010-02-16 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 5647-53 Citation Subset: IM |
Affiliation:
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NUST Center of Virology and Immunology, National University of Sciences & Technology, Sector H-12 Islamabad, Pakistan. yasir_waheed_199@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Transfusion
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adverse effects Databases, Factual Female Genotype* Health Education Hepacivirus* / genetics Hepatitis C / epidemiology*, etiology, mortality Humans Pakistan / epidemiology Pregnancy Risk Factors Risk-Taking Substance Abuse, Intravenous / complications |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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