Document Detail


Hepatitis C virus clearance is prominent in women in an endemic area.
MedLine Citation:
PMID:  11059937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The clinical and virological backgrounds of cases with previous hepatitis C virus (HCV) infection (positive for HCV antibody (anti-HCV) and HCV-RNA negative) in an HCV endemic area were examined to identify factors related to the clearance of HCV. METHODS: The study population comprised 3117 inhabitants, 1037 male and 2080 female, from an HCV endemic area. Hepatitis C virus antibody was detected by a passive haemagglutination test. The HCV-RNA and the HCV genotype were detected by using the polymerase chain reaction method. The HCV serotype was determined by enzyme immunoassay by using the peptides of the core region. RESULTS: Twenty-two per cent of the inhabitants were positive for anti-HCV, with males and the elderly having a significantly higher antibody titre (P < 0.01) than youths and females. Hepatitis C virus-RNA was detected in 78% of the HCV antibody-positive cases. The rate of HCV-RNA positivity was significantly higher in males than in females (P < 0.01). No relationship was found between HCV-RNA positivity and age. The HCV genotype 1b was the predominant genotype among the HCV-RNA-positive cases. Mixed genotypes (1b + 2a) were observed in 12% of cases, primarily in elderly males and females. In cases with previous HCV infection, serotype 1 was the most common serotype, and there appeared to be no relationship between the distribution of HCV serotypes and age and gender. There was a female predominance with regard to previous HCV infection, but not to being HCV carriers (P < 0.01). CONCLUSIONS: Gender, not HCV genotype, is the primary factor influencing HCV clearance.
Authors:
G Inoue; N Horiike; K Michitaka; M Onji
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  15     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-01-24     Completed Date:  2001-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  1054-8     Citation Subset:  IM    
Affiliation:
The Third Department of Internal Medicine, Ehime University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Distribution
Age Factors
Aged
Endemic Diseases
Female
Genotype
Hepacivirus / classification,  genetics,  immunology,  isolation & purification*
Hepatitis C / immunology,  virology*
Hepatitis C Antibodies / blood*
Humans
Immunoenzyme Techniques
Japan
Male
Middle Aged
Polymerase Chain Reaction
RNA, Viral / blood
Serotyping
Sex Distribution
Sex Factors
Chemical
Reg. No./Substance:
0/Hepatitis C Antibodies; 0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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