Document Detail


Hepatitis C virus-associated glomerulonephritis.
MedLine Citation:
PMID:  7648227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and is associated with a variety of extrahepatic manifestations, including cryoglobulinemia and glomerulonephritis. Epidemiologic evidence suggests that HCV infection may be a major risk factor for both cryoglobulinemic and type I membranoproliferative glomerulonephritis (MPGN). Clinical symptoms and laboratory data may or may not reflect the presence of chronic liver disease. Most patients have evidence of hypocomplementemia, circulating rheumatoid factors, and cryoglobulinemia. The pathogenesis of HCV-associated MPGN is probably a result of glomerular deposition of circulating HCV and anti-HCV antibodies. Treatment with interferon-alpha has been shown to improve proteinuria, suppress viremia, and stabilize renal function. However, patients often relapse after therapy is stopped. The optimal therapy remains to be defined but may involve different dosage regimens of interferon-alpha or the combination of several antiviral agents.
Authors:
C Stehman-Breen; R Willson; C E Alpers; D Gretch; R J Johnson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  4     ISSN:  1062-4821     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-27     Completed Date:  1995-09-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-94     Citation Subset:  IM    
Affiliation:
Division of Nephrology, University of Washington Medical Center, Seattle, USA.
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MeSH Terms
Descriptor/Qualifier:
Glomerulonephritis / etiology*,  pathology,  therapy,  virology
Hepacivirus*
Hepatitis C / complications*,  epidemiology,  pathology,  virology
Humans
Grant Support
ID/Acronym/Agency:
DK02142/DK/NIDDK NIH HHS; DK43422/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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