Document Detail

Hepatitis C virus (HCV) infection and liver-related mortality: a population-based cohort study in southern Italy. The Association for the Study of Liver Disease in Puglia.
MedLine Citation:
PMID:  11034979     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hepatitis C virus (HCV) is a common cause of chronic liver diseases but the degree to which these diseases contribute to liver-related mortality is not well established. The aim of this study was to estimate the absolute and relative effects of HCV infection on liver-related mortality. METHODS: A population random sample of 2472 subjects aged > or = 30 years was enrolled and followed up from 1985 to 1996. At enrollment, a structured interview and a clinical evaluation were performed. Serum samples were tested using HCV ELISA and RIBA HCV. Outcomes were overall and liver-related mortality and tracing procedures included review of office and hospital records, death certificates, and interviews with general practitioners, attending hospital and next of kin. Statistical analysis was performed using Poisson and binomial prospective data regression. RESULTS: Crude overall and liver-related mortality rates were 7.66 (95% CI : 6.68-8.79) and 0.9 (95% CI : 0.3-2.2) per 10(3) person-years, respectively. For HCV infection effect, incidence rate ratio and difference (per 10(3) person-year), risk ratio and difference were 27.5 (95% CI : 6.5-115.6), 4 (95% CI : 3-7), 33.1 (95% CI : 7.8- 139.3) and 0.06 (95% CI : 0.04-0.08), respectively; all measures were adjusted for age at death, sex and daily alcohol intake. CONCLUSIONS: The results show a strong relative but weak absolute effect of HCV infection on liver-related mortality in the 10-year period considered. Poisson and binomial models are virtually equivalent, but the choice of the summarizing measure of effect may have a different impact on health policy.
A R Osella; G Misciagna; V M Guerra; M Chiloiro; R Cuppone; A Cavallini; A Di Leo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of epidemiology     Volume:  29     ISSN:  0300-5771     ISO Abbreviation:  Int J Epidemiol     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-08     Completed Date:  2000-12-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  922-7     Citation Subset:  IM    
Laboratories of Epidemiology and Biostatistics, Medical Research Institute IRCCS Saverio De Bellis Castellana Grotte, Italy.
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MeSH Terms
Alcohol Drinking
Analysis of Variance
Binomial Distribution
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Hepacivirus / isolation & purification
Hepatitis C / epidemiology*,  mortality*
Italy / epidemiology
Middle Aged

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