Document Detail


Hepatitis C viremia and anti-HCV antibodies in alcoholics.
MedLine Citation:
PMID:  1380027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined serum hepatitis C status using a RIBA2 kit and a sensitive PCR procedure in 62 chronic alcoholics, 36 of whom had anti-HCV antibodies (Ab) detectable in an ELISA1 assay. Anti-HCV antibodies were detected in 22 patients using RIBA2. HCV RNA was detected by means of PCR in 18 patients who were RIBA2 positive and in none who were RIBA2 negative. Liver biopsies, available for 12 HCV RNA-positive patients, revealed histological features of purely alcohol-related lesions in seven and mixed alcohol-viral lesions in five. These results indicate that HCV replication is maintained in most alcoholics who score positive for anti-HCV Ab in the RIBA2 test, and that HCV viremia can be associated with histological features typical of alcoholic liver disease.
Authors:
B Nalpas; V Thiers; S Pol; F Driss; V Thepot; P Berthelot; C Brechot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hepatology     Volume:  14     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-09-15     Completed Date:  1992-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  381-4     Citation Subset:  IM    
Affiliation:
Unité d'Hépatologie, Hôpital Laënnec, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcoholism / complications,  microbiology*,  pathology
Base Sequence
Biopsy
DNA, Viral / genetics,  isolation & purification
Enzyme-Linked Immunosorbent Assay
Female
Hepacivirus / genetics,  isolation & purification*
Hepatitis Antibodies / analysis*
Hepatitis C / complications*,  pathology
Hepatitis C Antibodies
Humans
Liver / microbiology*,  pathology
Liver Cirrhosis, Alcoholic / microbiology*,  pathology
Male
Molecular Sequence Data
Oligodeoxyribonucleotides
Oligonucleotide Probes
Polymerase Chain Reaction
RNA, Viral / analysis,  genetics
Viremia / complications*,  pathology
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/Hepatitis Antibodies; 0/Hepatitis C Antibodies; 0/Oligodeoxyribonucleotides; 0/Oligonucleotide Probes; 0/RNA, Viral

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