Document Detail


Hepatitis C viraemia in adults with type 2 autoimmune hepatitis.
MedLine Citation:
PMID:  1658213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sera from 14 patients with type 2 autoimmune hepatitis (anti-LKM1 positive) were investigated for evidence of hepatitis C virus (HCV) infection. Antibodies to HCV were detected in 13 patients by both commercial and "in-house" ELISAs and also by a second generation recombinant immunoblot assay. Nine of the 13 (69%) anti-HCV positive patients were shown to be viraemic by a polymerase chain reaction-based assay for serum HCV RNA. Neither anti-HCV nor serum HCV RNA were detected in any of 6 controls with primary biliary cirrhosis or in 39 healthy blood donors. These findings strongly suggest a role for HCV in the pathogenesis of type 2 autoimmune hepatitis.
Authors:
J A Garson; M Lenzi; C Ring; F Cassani; G Ballardini; M Briggs; R S Tedder; F B Bianchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  34     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-12     Completed Date:  1991-12-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-6     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, School of Pathology, University College and Middlesex School of Medicine, London, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Autoimmune Diseases / microbiology*
Enzyme-Linked Immunosorbent Assay
Female
Hepacivirus / genetics,  immunology,  isolation & purification*
Hepatitis C / microbiology*
Hepatitis, Chronic / microbiology*
Humans
Immunoblotting
Italy
Liver Cirrhosis, Biliary / blood
Male
Middle Aged
Polymerase Chain Reaction
RNA, Viral / blood
Viremia / microbiology*
Chemical
Reg. No./Substance:
0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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