| Hepatitis C-associated hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 2169456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the United States, a large percentage of patients with hepatocellular carcinoma are serologically negative for hepatitis B. We conducted a retrospective study to determine the prevalence of hepatitis C antibody in the sera of 59 patients with hepatocellular carcinoma who were HBsAg-negative and had no evidence of alcoholic liver disease, primary biliary cirrhosis, autoimmune hepatitis, hemochromatosis or alpha 1-antitrypsin deficiency. Twenty patients (34%) were hepatitis C antibody-positive and hepatitis B core antibody-negative. All twenty patients had underlying cirrhosis, and seven (35%) had histories of transfusions. Eleven (19%) additional patients were also hepatitis C antibody-positive but were hepatitis B core antibody-positive as well. Twenty-one (36%) patients were both hepatitis C antibody- and hepatitis B core antibody-negative and seven (12%) were hepatitis C antibody-negative but hepatitis B core antibody-positive. The prevalence of hepatitis C antibody was also determined among three other population groups serving as controls and found to be 14% in 28 HbsAg-positive patients with hepatocellular carcinoma, 44% in 76 patients with cryptogenic cirrhosis and 0.5% in 200 consecutive volunteer blood donors. We conclude that hepatitis C antibody is prevalent among patients with hepatocellular carcinoma and may therefore be a common causative agent of this disease. A significant number of patients with and without cirrhosis, negative for hepatitis C antibody and hepatitis B core antibody, remain without a discernible cause for this malignancy. Perhaps a second- or third-generation test will detect hepatitis C antibody in some of these patients. |
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Authors:
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F Hasan; L J Jeffers; M De Medina; K R Reddy; T Parker; E R Schiff; M Houghton; Q L Choo; G Kuo |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 12 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1990-10-24 Completed Date: 1990-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 589-91 Citation Subset: IM |
Affiliation:
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Division of Hepatology, University of Miami School of Medicine. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Hepatocellular
/
epidemiology,
etiology*,
immunology Florida / epidemiology Hepatitis Antibodies / blood Hepatitis B Antibodies / blood Hepatitis B Core Antigens / immunology Hepatitis B Surface Antigens / blood Hepatitis C / complications*, epidemiology, immunology Hepatitis Viruses / immunology Hepatitis, Viral, Human / complications* Humans Liver Neoplasms / epidemiology, etiology*, immunology Prevalence Retrospective Studies Seroepidemiologic Studies |
| Chemical | |
Reg. No./Substance:
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0/Hepatitis Antibodies; 0/Hepatitis B Antibodies; 0/Hepatitis B Core Antigens; 0/Hepatitis B Surface Antigens |
| Comments/Corrections | |
Comment In:
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Hepatology. 1991 Nov;14(5):959
[PMID:
1657757
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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