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Hepatitis B virus infection is associated with deletion of chromosome 8p in Multiple Myeloma.
MedLine Citation:
PMID:  23033960     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Serological analyses within epidemiological cohort and case-control studies indicate to an association between HBV infection and risk of multiple myeloma (MM). To verify the relationship with an independent approach, we investigated the correlation between HBV positivity and chromosomal aberrations within 680 patients of the National Center for Tumor Diseases Heidelberg for which the serological HBV status (HBsAg and anti-HBc) and FISH data for 5 gains (1q21, 9q34, 11q23, 15q22, 19q13), 5 losses (6q21, 8p21, 13q14, 17p13, 22q11) and 3 IgH translocations (t(4,14), t(11,14), t(14,16)) were available. Deletion of 8p21 and 13q14 were shown associated with HBV positivity within hepatocellular carcinoma in other investigations. In the present evaluation, the odds ratio for loss of 8p21 was significantly elevated (OR=2.74, 95%CL=1.36-5.50, p=0.0048) and for loss of 13q14 non-significantly increased (OR=1.40, 95%CL=0.74-2.65) in anti-HBc positive patients. The results provide further support for a role of HBV infection in the pathogenesis of MM. n(A) (bst) =149 n(tot) =2477 © 2012 John Wiley & Sons A/S.
Authors:
Nikolaus Becker; Anne Byl; Susanne Friedrich; Anna Jauch; Paul Schnitzler; Gerlinde Egerer; Anthony D Ho; Hartmut Goldschmidt; Kai Neben
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Clinical Cancer Registry, National Center of Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.
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