| Hepatitis B virus deoxyribonucleic acid in serum during hepatitis B e antigen clearance in corticosteroid-treated severe chronic active hepatitis B. | |
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MedLine Citation:
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PMID: 3678739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between hepatitis B virus deoxyribonucleic acid in serum and histologic activity was determined in 11 patients with corticosteroid-treated severe chronic active hepatitis B who underwent clearance of hepatitis B e antigen. All patients cleared hepatitis B virus deoxyribonucleic acid from the serum, and clearance preceded the loss of hepatitis B e antigen by 9-49 mo (mean 24 +/- 4 mo). Seropositivity for hepatitis B virus deoxyribonucleic acid was always associated with histologic features of chronic active hepatitis. Resolution of histologic activity followed the loss of hepatitis B virus deoxyribonucleic acid from the serum and it preceded clearance of hepatitis B e antigen in all patients. A transient elevation of serum aspartate aminotransferase activity occurred in 5 patients at the time that absence of hepatitis B virus deoxyribonucleic acid in serum was first demonstrated, and it was followed by resolution of histologic activity. The serum level of hepatitis B virus deoxyribonucleic acid slowly decreased or remained unchanged in all but 1 patient during long-term corticosteroid therapy. We conclude that hepatitis B virus deoxyribonucleic acid in serum is associated with histologic activity in corticosteroid-treated patients with severe chronic active hepatitis B. Disappearance of hepatitis B virus deoxyribonucleic acid from the serum precedes the loss of histologic activity and clearance of hepatitis B e antigen. Serum hepatitis B virus deoxyribonucleic acid levels usually do not increase during long-term corticosteroid therapy. |
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Authors:
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J R Wood; A J Czaja; H F Taswell; J Ludwig; J Rakela; R Chase |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 93 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1987-12-28 Completed Date: 1987-12-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1225-30 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use* Adult Azathioprine / therapeutic use DNA, Viral / blood* Drug Therapy, Combination Follow-Up Studies Hepatitis B / drug therapy*, immunology Hepatitis B e Antigens / immunology* Hepatitis B virus / genetics* Hepatitis, Chronic / drug therapy*, immunology Humans Male Middle Aged Prednisone / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/DNA, Viral; 0/Hepatitis B e Antigens; 446-86-6/Azathioprine; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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