| Hepatitis B virus associated focal and segmental glomerular sclerosis: report of two cases and review of literature. | |
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MedLine Citation:
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PMID: 19169768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hepatitis B virus (HBV) is estimated to have infected about 350 million people worldwide, making it one of the most common human pathogens. Renal involvement is among its most common extra hepatic manifestations and usually manifests in the form of immune complex mediated glomerulopathy, such as membranous glomerulonephritis (MGN), membranoproliferative glomerulonephritis (MPGN), mesangioproliferative glomerulonephritis and immunoglobulin A (IgA) nephropathy. Occurrence of focal and segmental glomerular sclerosis (FSGS) with HBV infection is rare and only five cases have been reported earlier. We report two cases of hepatitis B associated FSGS. In both the cases, HBsAg was demonstrated in the renal tissue and both the cases showed response to treatment with lamivudine, thus indicating a possible causal association between the viral infection and occurrence of nephrotic syndrome. |
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Authors:
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Ambar Khaira; Bala Krishna Upadhyay; Alok Sharma; Prasenjit Das; Sandeep Mahajan; Govind Makhariya; Amit K Dinda; Sanjay K Agarwal; Suresh C Tiwari |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2009-01-24 |
Journal Detail:
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Title: Clinical and experimental nephrology Volume: 13 ISSN: 1437-7799 ISO Abbreviation: Clin. Exp. Nephrol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-06 Completed Date: 2009-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709923 Medline TA: Clin Exp Nephrol Country: Japan |
Other Details:
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Languages: eng Pagination: 373-7 Citation Subset: IM |
Affiliation:
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Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biopsy DNA, Viral / blood Glomerulosclerosis, Focal Segmental / drug therapy, virology* Hepatitis B / complications*, diagnosis, drug therapy Hepatitis B Antigens / analysis* Hepatitis B Core Antigens / analysis Hepatitis B Surface Antigens / analysis Hepatitis B virus / genetics, immunology* Humans Immunohistochemistry Kidney / virology* Lamivudine / therapeutic use Male Nephrotic Syndrome / drug therapy, virology* Proteinuria / virology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/Hepatitis B Antigens; 0/Hepatitis B Core Antigens; 0/Hepatitis B Surface Antigens; 134678-17-4/Lamivudine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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