Document Detail


Hepatitis B virus antigen quantitation by radioimmunoassay (RIA) in viral hepatitis and in chronic liver diseases.
MedLine Citation:
PMID:  804225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of HBAg in viral hepatitis, in chronic active hepatitis and in cirrhosis has been investigated by using immunological methods and a solid-phase radioimmunoassay. RIA demonstrated as positive: 90% of 20 patients with posttransfusion hepatitis; 88% of 50 patients with acute viral hepatitis; 100% of 13 patients with chronic active hepatitis and 35% of 20 patients with cirrhosis; whereas the frequency of HBAg in the same patients appeared to be lower by AGD, CIEP and CF. The measure of antigenaemia has been obtained by use of HBAg (ad) dose response standard curve. The quantitative HBAg data of an eight-week follow-up of fully recovered 15 patients with acute hepatitis are reported. In the first week it appeared a distribution of the HBAg levels into three classes of values. The concentration of HBAg in the serum became lower week by week and in 8th week the antigen was no longer detectable. The radioimmunoquantitation of HBAg in the serum of patients suffering from chronic acitve hepatitis and cirrhosis showed wide levels of antigenaemia ranging between 17 and 5100 ng ad equivalent/ml. The use of a dose response standard curve in order to quantify HBAg in the serum represents a further increased sensitivity of RIA.
Authors:
F De Ritis; E Gravina; G Squame
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta hepato-gastroenterologica     Volume:  22     ISSN:  0300-970X     ISO Abbreviation:  Acta Hepatogastroenterol (Stuttg)     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-05-29     Completed Date:  1975-05-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0340734     Medline TA:  Acta Hepatogastroenterol (Stuttg)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  4-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Blood Transfusion / adverse effects
Child
Chronic Disease
Complement Fixation Tests
Female
Hepatitis / microbiology
Hepatitis B / microbiology*
Hepatitis B Antigens / analysis*
Humans
Immunodiffusion
Immunoelectrophoresis
Liver Cirrhosis / microbiology
Liver Diseases / immunology,  microbiology*
Male
Middle Aged
Radioimmunoassay*
Chemical
Reg. No./Substance:
0/Hepatitis B Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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