| Hepatitis B virus antigen quantitation by radioimmunoassay (RIA) in viral hepatitis and in chronic liver diseases. | |
| | |
MedLine Citation:
|
PMID: 804225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The incidence of HBAg in viral hepatitis, in chronic active hepatitis and in cirrhosis has been investigated by using immunological methods and a solid-phase radioimmunoassay. RIA demonstrated as positive: 90% of 20 patients with posttransfusion hepatitis; 88% of 50 patients with acute viral hepatitis; 100% of 13 patients with chronic active hepatitis and 35% of 20 patients with cirrhosis; whereas the frequency of HBAg in the same patients appeared to be lower by AGD, CIEP and CF. The measure of antigenaemia has been obtained by use of HBAg (ad) dose response standard curve. The quantitative HBAg data of an eight-week follow-up of fully recovered 15 patients with acute hepatitis are reported. In the first week it appeared a distribution of the HBAg levels into three classes of values. The concentration of HBAg in the serum became lower week by week and in 8th week the antigen was no longer detectable. The radioimmunoquantitation of HBAg in the serum of patients suffering from chronic acitve hepatitis and cirrhosis showed wide levels of antigenaemia ranging between 17 and 5100 ng ad equivalent/ml. The use of a dose response standard curve in order to quantify HBAg in the serum represents a further increased sensitivity of RIA. |
| | |
Authors:
|
F De Ritis; E Gravina; G Squame |
Related Documents
:
|
7430385 - Marrow hypoplasia with splenomegaly in adolescence. 9719235 - Natural course of portal hemodynamics in patients with chronic liver diseases, evaluate... 9923925 - Fibrosis/cirrhosis after orthotopic liver transplantation. 15270715 - Nitric oxide and the hyperdynamic circulation in cirrhosis: is there a role for selecti... 22227585 - Hiv treatment as prevention and hptn 052. 20306555 - Significantly diminished long-term specificity of the bed capture enzyme immunoassay am... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Acta hepato-gastroenterologica Volume: 22 ISSN: 0300-970X ISO Abbreviation: Acta Hepatogastroenterol (Stuttg) Publication Date: 1975 Feb |
Date Detail:
|
Created Date: 1975-05-29 Completed Date: 1975-05-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0340734 Medline TA: Acta Hepatogastroenterol (Stuttg) Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 4-13 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adolescent Adult Blood Transfusion / adverse effects Child Chronic Disease Complement Fixation Tests Female Hepatitis / microbiology Hepatitis B / microbiology* Hepatitis B Antigens / analysis* Humans Immunodiffusion Immunoelectrophoresis Liver Cirrhosis / microbiology Liver Diseases / immunology, microbiology* Male Middle Aged Radioimmunoassay* |
| Chemical | |
Reg. No./Substance:
|
0/Hepatitis B Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An inhibitor to erythrocyte agglutination in bovine albumin preparations.
Next Document: Findings in routine laboratory examination in progressive myoclonus epilepsy.