Document Detail

Hepatitis B viremia is associated with increased risk of hepatocellular carcinoma in chronic carriers.
MedLine Citation:
PMID:  14635008     Owner:  NLM     Status:  MEDLINE    
The role of quantitative viral load in development of hepatocellular carcinoma (HCC) among chronic hepatitis B virus (HBV) carriers was evaluated using real-time PCR (TaqMan PCR), a highly sensitive method for quantitative detection of HBV DNA. Serum samples collected at study entry from HCC cases and matched controls were chosen separately from ongoing prospective cohort studies in Senegal, West Africa, and Haimen City, China. For 14 HCC cases and 28 controls from Senegal, the relative risk (RR, 95% CI) of HCC was 15.6 (2.0-124.3) for those positive by the TaqMan PCR assay. Average length of follow-up (study entry to death from HCC) among cases was 2.8 (+/-1.6) years. The paired median difference between cases and controls was 3.8 x 10(4) virions/ml, with cases higher (P = 0.09). In order to clarify the relationship with lower-titer viremia, we selected 55 cases and 55 matched controls from the Chinese cohort all negative for serum HBV DNA by conventional dot blot hybridization. In this group, the RR associated with HBV DNA positivity by TaqMan PCR was 3.1 (1.1-9.2), with an average duration of follow-up of 3.3 (+/-2.1) years. The median difference in quantitative viremia between cases and controls was 6.0 x 10(4) virions/ml, with cases higher (P < 0.0001). Increased risk appeared to be confined to subjects with viral loads >2.3 x 10(4) virions/ml. In conclusion, HBV viremia, except perhaps at extremely low levels, is associated with increased risk for HCC in prospective studies of chronic carriers in two disparate populations.
Baiqing Tang; Warren D Kruger; Gang Chen; Fumin Shen; Wen Yao Lin; Souleymane Mboup; W Thomas London; Alison A Evans
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of medical virology     Volume:  72     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-11-24     Completed Date:  2004-02-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
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MeSH Terms
Carcinoma, Hepatocellular / epidemiology*,  virology
Carrier State / virology*
Case-Control Studies
Cohort Studies
DNA, Viral / analysis
Hepatitis B virus
Hepatitis B, Chronic / complications*,  virology
Liver Neoplasms / epidemiology*,  virology
Middle Aged
Military Personnel
Polymerase Chain Reaction
Prospective Studies
Taq Polymerase
Viral Load
Viremia / complications*,  virology
Grant Support
Reg. No./Substance:
0/DNA, Viral; EC 2.7.7.-/Taq Polymerase

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