| Hepatitis B post-partum e antigen clearance in hepatitis B carrier mothers: Correlation with viral characteristics. | |
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MedLine Citation:
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PMID: 16638107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The purpose of the present paper was to correlate hepatitis B virus (HBV) genotype, e antigen titer, HBV-DNA level and precore/basal core promoter mutations with post-partum e antigen clearance in hepatitis B e antigen (HBeAg)-positive carrier mothers. METHODS: A total of 40 consecutive HBeAg-positive carrier mothers were studied from January 2002 to January 2003. The blood samples were taken at delivery, 3-4 months and at 1 year after delivery, and the follow-up period was until 1 year after delivery. All sera were assayed for HBeAg, HBV-DNA level, HBV genotype and precore/basal core promoter mutations. The correlation between HBV characteristics and post-partum e antigen clearance was analyzed by Mann-Whitney, Pearson chi2 and multiple logistic regression tests. RESULTS: The mean age of the 40 HBeAg-positive carrier mothers was 29.9 +/- 5.3 years with a mean parity of 1.4 +/- 0.7. Five of them (group I) had post-partum e antigen clearance, which persisted thereafter, whereas the remaining 35 carrier mothers (group II) had persistent positivity of HBeAg during the follow-up period. The prepartum comparisons of HBV characteristics between groups I and II were comparable in terms of demographics and distributions of HBV genotype and precore/basal core promoter mutations. In contrast, group I carrier mothers had lower HBeAg titer and HBV-DNA level than group II carrier mothers (1:80 vs 1:4000, P = 0.02, and 3.75 x 10(5) vs 3 x 10(8) copies/mL, P = 0.028, respectively). CONCLUSIONS: Post-partum e antigen clearance in HBeAg-positive carrier mothers is closely associated with prepartum low HBeAg titer or HBV-DNA level. |
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Authors:
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Ho-Hsiung Lin; Wen-Yih Wu; Jia-Horng Kao; Ding-Shin Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 21 ISSN: 0815-9319 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-04-26 Completed Date: 2006-10-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
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Languages: eng Pagination: 605-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan. hhlin@ha.mc.ntu.edu.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chi-Square Distribution DNA, Viral / analysis Female Genotype Hepatitis B / immunology* Hepatitis B e Antigens / analysis* Humans Postpartum Period* Pregnancy Pregnancy Complications, Infectious / immunology*, microbiology Statistics, Nonparametric Virus Replication |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/Hepatitis B e Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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