| Hepatitis B e antigen levels and response to peginterferon: influence of precore and basal core promoter mutants. | |
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MedLine Citation:
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PMID: 23274785 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hepatitis B e antigen (HBeAg) levels may predict response to peginterferon (PEG-IFN) but are also influenced by presence of precore(PC) and core promoter(BCP) mutants. HBeAg was measured in 214 patients treated with PEG-IFN±lamivudine for 52 weeks. Patients were classified at baseline as wildtype (WT) or non-WT (detectable PC/BCP mutants). Combined response (HBeAg loss with HBV DNA<2,000 IU/mL), HBeAg response (HBeAg loss with HBV DNA>2,000 IU/mL) or non-response was assessed at week 78. Mean baseline HBeAg levels were 2.65 logIU/mL in combined responders, 2.48 in non-responders and 2.24 in HBeAg responders(p=0.034). Baseline HBeAg levels were not associated with combined response after stratification by WT/non-WT. Within the PEG-IFN monotherapy group(n=104), patients with HBeAg <1 logIU/mL at week 24 had a higher probability of combined response (29% versus 12%,p=0.041). After stratification by WT/non-WT, WT patients with HBeAg <1logIU/mL at week 24 had a probability of combined response of 78% (versus 19% in patients with >1logIU/mL,p<0.001), whereas no difference in response rates was observed in non-WT patients (p=0.848). The relationship between HBeAg levels and response to PEG-IFN depends upon the presence of PC/BCP mutants. HBeAg levels should therefore not be routinely used to select patients for PEG-IFN, nor for monitoring of therapy. |
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Authors:
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Milan J Sonneveld; Vincent Rijckborst; Louwerens Zwang; Stefan Zeuzem; E Jenny Heathcote; Krzysztof Simon; Roeland Zoutendijk; Ulus S Akarca; Suzan D Pas; Bettina E Hansen; Harry L A Janssen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-26 |
Journal Detail:
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Title: Antiviral research Volume: - ISSN: 1872-9096 ISO Abbreviation: Antiviral Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109699 Medline TA: Antiviral Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Departments of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Electronic address: j.sonneveld@erasmusmc.nl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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