Document Detail


Hepatitis B e antigen levels and response to peginterferon: influence of precore and basal core promoter mutants.
MedLine Citation:
PMID:  23274785     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hepatitis B e antigen (HBeAg) levels may predict response to peginterferon (PEG-IFN) but are also influenced by presence of precore(PC) and core promoter(BCP) mutants. HBeAg was measured in 214 patients treated with PEG-IFN±lamivudine for 52 weeks. Patients were classified at baseline as wildtype (WT) or non-WT (detectable PC/BCP mutants). Combined response (HBeAg loss with HBV DNA<2,000 IU/mL), HBeAg response (HBeAg loss with HBV DNA>2,000 IU/mL) or non-response was assessed at week 78. Mean baseline HBeAg levels were 2.65 logIU/mL in combined responders, 2.48 in non-responders and 2.24 in HBeAg responders(p=0.034). Baseline HBeAg levels were not associated with combined response after stratification by WT/non-WT. Within the PEG-IFN monotherapy group(n=104), patients with HBeAg <1 logIU/mL at week 24 had a higher probability of combined response (29% versus 12%,p=0.041). After stratification by WT/non-WT, WT patients with HBeAg <1logIU/mL at week 24 had a probability of combined response of 78% (versus 19% in patients with >1logIU/mL,p<0.001), whereas no difference in response rates was observed in non-WT patients (p=0.848). The relationship between HBeAg levels and response to PEG-IFN depends upon the presence of PC/BCP mutants. HBeAg levels should therefore not be routinely used to select patients for PEG-IFN, nor for monitoring of therapy.
Authors:
Milan J Sonneveld; Vincent Rijckborst; Louwerens Zwang; Stefan Zeuzem; E Jenny Heathcote; Krzysztof Simon; Roeland Zoutendijk; Ulus S Akarca; Suzan D Pas; Bettina E Hansen; Harry L A Janssen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-26
Journal Detail:
Title:  Antiviral research     Volume:  -     ISSN:  1872-9096     ISO Abbreviation:  Antiviral Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109699     Medline TA:  Antiviral Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Departments of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Electronic address: j.sonneveld@erasmusmc.nl.
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