Document Detail


Hepatitis B Therapy in Pregnancy.
MedLine Citation:
PMID:  20949113     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
All decisions about initiating, continuing, or stopping therapy of the hepatitis B virus (HBV) during pregnancy must include an analysis of the risks and benefits for mother and fetus. The trimester of the pregnancy and the stage of the mother's liver disease are important factors. Treatment in the third trimester may be initiated to aid in preventing perinatal transmission, which appears to be most pronounced in mothers with high viral loads. Consideration of initiating treatment in the third trimester should occur after a high viral load is documented in the latter part of the second trimester, to allow adequate time for initiation of antiviral therapy with significant viral suppression before delivery. This discussion should include the topic of breastfeeding, because it is generally not recommended while receiving antiviral therapy. Currently, lamivudine and tenofovir appear to be the therapeutic options with the most reasonable safety data in pregnancy.
Authors:
Natalie H Bzowej
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-9-9
Journal Detail:
Title:  Current hepatitis reports     Volume:  9     ISSN:  1541-0706     ISO Abbreviation:  -     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101172422     Medline TA:  Curr Hepat Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  197-204     Citation Subset:  -    
Affiliation:
California Pacific Medical Center, 2340 Clay Street, Suite 312, San Francisco, CA 94115 USA.
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