Document Detail


Hepatitis B and D genomes in hepatitis B surface antigen negative patients with chronic hepatitis C.
MedLine Citation:
PMID:  7539829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatitis B and hepatitis D viral genomes were tested by nested polymerase chain reaction in the serum and liver of 69 hepatitis B surface antigen (HBsAg) negative, anti-hepatitis C virus (HCV) positive patients (47 with HCV RNA and 22 without HCV RNA). Serum hepatitis B virus (HBV) DNA-was detected in 49% of the patients with HCV-RNA and in 64% of those without HCV-RNA. Furthermore, intrahepatic HBV-DNA was found in four of five (80%) of the biopsies analysed. Delta genome was found in 72% and 73%, respectively, of the anti-HCV positive patients with or without HCV-RNA. In addition, intrahepatic delta virus genome was detected in another four liver biopsies studied. In the group of patients with HCV-RNA, the simultaneous presence of hepatitis B and D genomes was statistically higher in transfused patients than in drug addicts, or in those with an unknown infection route (P < 0.001). These results show a high percentage of B and D genomes in HBsAg negative patients with anti-HCV, irrespective of the presence or absence of the HCV genome. However, the clinical implications of this finding should be examined in future studies.
Authors:
S González; S Navas; A Madejón; J Bartolomé; I Castillo; G Moraleda; J Martín; E Marriott; M Herrero; V Carreño
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical virology     Volume:  45     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-07-12     Completed Date:  1995-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  168-73     Citation Subset:  IM    
Affiliation:
Hepatology Unit, Fundación Jiménez Díaz, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
DNA Primers / genetics
Genome, Viral
Hepacivirus / immunology
Hepatitis Antibodies / blood
Hepatitis B Surface Antigens / blood,  isolation & purification
Hepatitis B virus / genetics,  isolation & purification*
Hepatitis C / immunology,  virology*
Hepatitis C Antibodies
Hepatitis Delta Virus / genetics,  isolation & purification*
Hepatitis, Chronic / immunology,  virology*
Humans
Liver / virology
Male
Polymerase Chain Reaction
RNA, Viral / blood,  genetics,  isolation & purification
Chemical
Reg. No./Substance:
0/DNA Primers; 0/Hepatitis Antibodies; 0/Hepatitis B Surface Antigens; 0/Hepatitis C Antibodies; 0/RNA, Viral

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