| Hepatitis B and D genomes in hepatitis B surface antigen negative patients with chronic hepatitis C. | |
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MedLine Citation:
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PMID: 7539829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatitis B and hepatitis D viral genomes were tested by nested polymerase chain reaction in the serum and liver of 69 hepatitis B surface antigen (HBsAg) negative, anti-hepatitis C virus (HCV) positive patients (47 with HCV RNA and 22 without HCV RNA). Serum hepatitis B virus (HBV) DNA-was detected in 49% of the patients with HCV-RNA and in 64% of those without HCV-RNA. Furthermore, intrahepatic HBV-DNA was found in four of five (80%) of the biopsies analysed. Delta genome was found in 72% and 73%, respectively, of the anti-HCV positive patients with or without HCV-RNA. In addition, intrahepatic delta virus genome was detected in another four liver biopsies studied. In the group of patients with HCV-RNA, the simultaneous presence of hepatitis B and D genomes was statistically higher in transfused patients than in drug addicts, or in those with an unknown infection route (P < 0.001). These results show a high percentage of B and D genomes in HBsAg negative patients with anti-HCV, irrespective of the presence or absence of the HCV genome. However, the clinical implications of this finding should be examined in future studies. |
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Authors:
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S González; S Navas; A Madejón; J Bartolomé; I Castillo; G Moraleda; J Martín; E Marriott; M Herrero; V Carreño |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medical virology Volume: 45 ISSN: 0146-6615 ISO Abbreviation: J. Med. Virol. Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-07-12 Completed Date: 1995-07-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 168-73 Citation Subset: IM |
Affiliation:
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Hepatology Unit, Fundación Jiménez Díaz, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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DNA Primers
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genetics Genome, Viral Hepacivirus / immunology Hepatitis Antibodies / blood Hepatitis B Surface Antigens / blood, isolation & purification Hepatitis B virus / genetics, isolation & purification* Hepatitis C / immunology, virology* Hepatitis C Antibodies Hepatitis Delta Virus / genetics, isolation & purification* Hepatitis, Chronic / immunology, virology* Humans Liver / virology Male Polymerase Chain Reaction RNA, Viral / blood, genetics, isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Hepatitis Antibodies; 0/Hepatitis B Surface Antigens; 0/Hepatitis C Antibodies; 0/RNA, Viral |
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