Document Detail

Hepatic veno-occlusive disease.
MedLine Citation:
PMID:  3526887     Owner:  NLM     Status:  MEDLINE    
Hepatic veno-occlusive disease is a nonthrombotic obliteration of small intrahepatic veins by loose connective tissue. The venous occlusion may be progressive and lead to massive hepatocellular necrosis. Although originally described as a result of intoxication with plant alkaloids, it is now seen as a complication of high-dose antineoplastic chemotherapy, especially in the setting of bone marrow transplantation. The incidence of hepatic veno-occlusive disease after bone marrow transplantation approaches 20 percent, with mortality ranging from 7 to 50 percent. The clinical diagnosis may be quite accurate (as confirmed by biopsy or autopsy) and is based on the triad of jaundice, hepatomegaly and/or right upper quadrant pain, and ascites or unexplained weight gain. The pathogenesis is obscure but most likely relates to drug-induced venous endothelial damage. At the present time, therapy for veno-occlusive disease of the liver remains supportive. As intensive chemotherapy regimens (with or without bone marrow support) become more widely applied, it is expected that this disease will be encountered more frequently.
B J Rollins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  81     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-25     Completed Date:  1986-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  297-306     Citation Subset:  AIM; IM    
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MeSH Terms
Antineoplastic Agents / adverse effects
Bone Marrow Transplantation*
Hepatic Veins / pathology*
Liver Diseases / diagnosis,  etiology*,  pathology
Grant Support
5-T32-CA09172-10/CA/NCI NIH HHS
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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