| Hepatic ultrastructure after methotrexate therapy for rheumatoid arthritis. | |
| | |
MedLine Citation:
|
PMID: 3196365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Twenty-six patients receiving long-term oral methotrexate (MTX) therapy for rheumatoid arthritis (24 patients) or psoriasis (2 patients) were prospectively evaluated for alterations in liver morphology by light microscopy, electron microscopy, and immunofluorescence microscopy. Although only 4 MTX-treated patients had light microscopic evidence of mild fibrosis, all had evidence of collagen deposition in the space of Disse near Ito cells and changes in hepatocyte lysosomes on electron microscopy. These findings were absent from control livers. Fibrinogen, fibronectin, and type IV collagen were identified by immunofluorescence in both MTX-treated patients and controls. We conclude that long-term MTX therapy for rheumatoid arthritis is associated with alterations in hepatic ultrastructure, including collagen deposition in the space of Disse and changes in hepatocyte lysosomes. |
| | |
Authors:
|
D J Bjorkman; E H Hammond; R G Lee; D O Clegg; K G Tolman |
Related Documents
:
|
1105775 - Occurrence of amyloid in the teeth-supporting tissues of patients with rheumatoid disea... 1586255 - Adult onset still's disease: clinical experience with 18 patients over 15 years in nort... 20107565 - Differentiation of psra due to group a and due to nongroup a streptococci in patients w... 424825 - Rheumatic fever and gonococcal pharyngitis in an adult. 7904545 - Soluble intercellular adhesion molecule-1 (icam-1) in sera and bronchoalveolar lavage f... 9759985 - Vascular and neuroendocrine components in altered blood pressure regulation after surgi... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Arthritis and rheumatism Volume: 31 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 1988 Dec |
Date Detail:
|
Created Date: 1989-01-10 Completed Date: 1989-01-10 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1465-72 Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine, Veterans Administration Hospital, Salt Lake City, Utah. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Arthritis, Rheumatoid / drug therapy* Collagen / metabolism Drug-Induced Liver Injury* Female Humans Liver / cytology, metabolism, ultrastructure* Liver Diseases / metabolism, pathology Lysosomes / drug effects Male Methotrexate / adverse effects*, therapeutic use Microscopy Microscopy, Electron Microscopy, Fluorescence Middle Aged Prospective Studies |
| Grant Support | |
ID/Acronym/Agency:
|
RR-64/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
59-05-2/Methotrexate; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Histopathologic findings in the liver of rheumatoid arthritis patients treated with long-term bolus ...
Next Document: Reduced natural killer cell activity in patients with systemic sclerosis. Correlation with clinical ...