Document Detail


Hepatic triglyceride lipase deficiency in liver disease.
MedLine Citation:
PMID:  865246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activity of post-heparin lipases in patients with alcoholic hepatitis and viral hepatitis was evaluated. Lipoprotein lipase and hepatic triglyceride lipase were differentiated by assay under high and low salt conditions and also by separation on heparin-agarose affinity chromatography columns. The mean activity of hepatic triglyceride lipase in the sera of liver disease patients was only 21-24% of the mean of controls, but lipoprotein lipase in patients' sera was not different from normal levels. Hepatic triglyceride lipase deficiency may partially account for the accumulation of a triglyceride-rich low density lipoprotein in liver disease.
Authors:
M Freeman; L Kuiken; J B Ragland; S M Sabesin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  12     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-07-23     Completed Date:  1977-07-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  443-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / complications
Drug-Induced Liver Injury / enzymology*
Female
Hepatitis, Viral, Human / enzymology*
Humans
Lipase / metabolism*
Lipoprotein Lipase / metabolism*
Liver / enzymology*
Male
Chemical
Reg. No./Substance:
EC 3.1.1.3/Lipase; EC 3.1.1.34/Lipoprotein Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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