| Hepatic toxicity and recovery of Fischer 344 rats following exposure to 2-aminoanthracene by intraperitoneal injection. | |
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MedLine Citation:
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PMID: 11442019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Humans may be exposed to 2-aminoanthracene (2-AA), a substituted polycyclic aromatic hydrocarbon, and a recognized mutagen and carcinogen, through oral and respiratory routes from contact with a variety of environmental sources. For the present study, we sought to evaluate hepatic damage and recovery in Fischer 344 rats following multiple i.p. injections of 5 mg of 2-AA. Rats were injected weekly for up to 5 weeks. Subgroups were then allowed to recover for 1, 5, or 9 weeks, and biochemical and pathologic changes were evaluated. We observed that weight gains were reduced relative to controls for all groups receiving > or = 2 injections. Serum enzyme levels indicative of liver damage were evident and included alterations in serum aspartate aminotransferase, alkaline phosphatase, total protein, albumin, and globulin. These alterations usually returned to normal by 5 weeks following cessation of 2-AA administration. In contrast, histologic liver changes, including hepatocyte hypertrophy, biliary hyperplasia with oval cell proliferation, altered foci, nodular hyperplasia, and one hepatocellular adenoma became more severe with time. This experiment demonstrates patterns of hepatic damage and recovery in rats exposed to 2-AA. |
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Authors:
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D G Baker; H W Taylor; S P Lee; S A Barker; M E Goad; J C Means |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Toxicologic pathology Volume: 29 ISSN: 0192-6233 ISO Abbreviation: Toxicol Pathol Publication Date: 2001 May-Jun |
Date Detail:
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Created Date: 2001-07-09 Completed Date: 2001-12-04 Revised Date: 2009-07-01 |
Medline Journal Info:
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Nlm Unique ID: 7905907 Medline TA: Toxicol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 328-32 Citation Subset: IM |
Affiliation:
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Department of Veterinary Pathology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA. dbaker@mail.vetmed.lsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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chemically induced,
pathology Albumins / analysis Alkaline Phosphatase / blood Animals Anthracenes / administration & dosage, toxicity* Aspartate Aminotransferases / blood Blood Proteins / analysis Body Weight / drug effects Carcinogens / administration & dosage, toxicity* Disease-Free Survival Focal Nodular Hyperplasia / chemically induced, pathology Globulins / analysis Injections, Intraperitoneal Liver / drug effects*, pathology Liver Neoplasms / chemically induced, pathology Male Mutagens / administration & dosage, toxicity* Rats Rats, Inbred F344 Remission Induction Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Anthracenes; 0/Blood Proteins; 0/Carcinogens; 0/Globulins; 0/Mutagens; 613-13-8/2-anthramine; EC 2.6.1.1/Aspartate Aminotransferases; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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