Document Detail

Hepatic support with hepatocyte suspensions in a permeable membrane dialyzer.
MedLine Citation:
PMID:  918848     Owner:  NLM     Status:  MEDLINE    
Hepatic support by whole liver, liver slice, or hepatocyte perfusion is unsatisfactory. A new concept of support with circulating hepatocytes on one side of a cuprophan membrane and blood from an anhepatic pig on the other was evaluated in 19 dialysis experiments. Levels of pyruvate metabolism and oxygen utilization were similar to those obtained when liver cells in a centrifuge are perfused with oxygenated plasma. Of six anhepatic pigs given late hepatic support, five showed neurologic improvement. One had concomitant improvement in electroencephalographic results. A membrane hemodiolysis unit in which hepatocytes circulate against blood from an anhepatic animal is the most suitable extracorporeal liver support unit described so far. Its simplicity allows repeated and prolonged use.
F Olumide; A Eliashiv; N Kralios; L Norton; B Eiseman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  82     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  599-606     Citation Subset:  AIM; IM    
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MeSH Terms
Bilirubin / metabolism
Blood Glucose / metabolism
Blood Urea Nitrogen
Hemoperfusion / methods*
Hepatic Encephalopathy / etiology,  therapy*
Kidney, Artificial
Liver / cytology,  metabolism
Models, Biological
Oxygen Consumption
Oxygenators, Membrane*
Pyruvates / metabolism
Trypan Blue
Reg. No./Substance:
0/Blood Glucose; 0/Pyruvates; 635-65-4/Bilirubin; 72-57-1/Trypan Blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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