Document Detail

Hepatic 'stem cell' malignancies in adults: four cases.
MedLine Citation:
PMID:  12940779     Owner:  NLM     Status:  MEDLINE    
AIMS: Combined hepatocellular/cholangiocarcinomas have been explained by some investigators as bidirectional differentiation of neoplastic progenitor cell populations. The presence of hepatic progenitor cells has now been confirmed in humans, though whether they can give rise to malignant tumours has not been confirmed. We report four cases of small tumours identified in livers with features of chronic hepatitis which may suggest a role for malignant transformation of hepatic stem cells in hepatic malignancies. METHODS: Tumour samples were studied from four patients by histochemistry and immunohistochemistry. RESULTS: Two patients had chronic hepatitis B, one had chronic hepatitis C and chronic alcoholic liver injury, and one had non-B non-C chronic hepatitis. Stages of disease ranged from portal fibrosis to cirrhosis. All tumours contained undifferentiated cells with morphological and immunohistochemical features that would be expected of hepatic progenitor cells. These cells merged with both hepatocellular carcinoma and cholangiocarcinoma components as well as with mature appearing hepatocytes within the tumours. CONCLUSION: We suggest that these tumours are of hepatic progenitor cell origin, supporting the concepts that human hepatocarcinogenesis can be based on transformation of progenitor cells and that such a process may underlie development of some mixed hepatocellular/cholangiocarcinomas and dysplastic nodules.
N D Theise; J L Yao; K Harada; P Hytiroglou; B Portmann; S N Thung; W Tsui; H Ohta; Y Nakanuma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  43     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-27     Completed Date:  2004-04-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  263-71     Citation Subset:  IM    
Department of Pathology, New York University Medical Center, New York, NY, USA.
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MeSH Terms
Carcinoma, Hepatocellular / pathology
Cell Transformation, Neoplastic / pathology*
Cholangiocarcinoma / pathology
Hepatitis, Chronic / complications,  pathology*
Liver Neoplasms / complications,  pathology*
Middle Aged
Stem Cells / pathology*

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