| Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation. | |
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MedLine Citation:
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PMID: 19434726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSION: HSCs express CXCR4 receptor in vivo and in vitro. CXCR4 receptor activation by SDF-1alpha is profibrogenic through its effects on HSC activation, fibrogenesis, and proliferation. Extracellular signal-regulated kinase 1/2 and phosphoinositide 3-kinase pathways mediate SDF-1alpha-induced effects on HSC expression of collagen I and proliferation. The availability of small molecule inhibitors of CXCR4 make this receptor an appealing target for antifibrotic approaches. |
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Authors:
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Feng Hong; Ana Tuyama; Ting Fang Lee; Johnny Loke; Ritu Agarwal; Xin Cheng; Anita Garg; M Isabel Fiel; Myron Schwartz; Jose Walewski; Andrea Branch; Alison D Schecter; Meena B Bansal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 49 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-03 Completed Date: 2009-07-01 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 2055-67 Citation Subset: IM |
Affiliation:
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Mount Sinai School of Medicine, New York, NY 10029, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Proliferation Cells, Cultured Chemokine CXCL12 / physiology* Collagen Type I / biosynthesis Hepatic Stellate Cells / cytology, metabolism*, physiology Humans Liver Cirrhosis / metabolism* Receptors, CXCR4 / biosynthesis* Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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K08 DK060474-05/DK/NIDDK NIH HHS; R03 DK071745-01A1/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/CXCR4 protein, human; 0/Chemokine CXCL12; 0/Collagen Type I; 0/Receptors, CXCR4 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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