| Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance. | |
| | |
MedLine Citation:
|
PMID: 20939105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Non-alcoholic fatty liver disease (NAFLD), a further expression of metabolic syndrome, strictly linked to obesity and diabetes mellitus, is characterized by insulin resistance (IR), elevated serum levels of free fatty acids and fatty infiltration of the liver, which is known as hepatic steatosis. Hepatocyte apoptosis is a key feature of this disease and correlates with its severity. Free-fatty-acid-induced toxicity represents one of mechanisms for the pathogenesis of NAFLD and hormones, growth factors and adipokines influence also play a key role. This review highlights the various pathways that contribute to the development of hepatic steatosis. Circulating concentrations of inflammatory cytokines are reckoned to be the most important factor in causing and maintaining IR. Low-grade chronic inflammation is fundamental in the progression of NAFLD toward higher risk cirrhotic states. |
| | |
Authors:
|
Giovanni Tarantino; Silvia Savastano; Annamaria Colao |
Related Documents
:
|
8528285 - Expression of a single-chain fv antibody against abscisic acid creates a wilty phenotyp... 11355745 - Inhibition of thyroid hormone binding to the nuclear receptor by mobilization of free f... 3168955 - Thyroid hormone structure-activity relationships: molecular structure of 3,5,3'-triiodo... 21352605 - Transport characteristics of guanidino compounds at the blood-brain barrier and blood-c... 19403305 - Optimization of medium composition for butyric acid production by clostridium thermobut... 8418885 - Determination of lipid hydroperoxides in native low-density lipoprotein by a chemilumin... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: World journal of gastroenterology : WJG Volume: 16 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-12 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
|
Languages: eng Pagination: 4773-83 Citation Subset: IM |
Affiliation:
|
Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, Italy. tarantin@unina.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipokines
/
metabolism* Animals Cardiovascular Diseases / physiopathology Chronic Disease Fatty Liver / etiology, physiopathology* Hormones / metabolism* Humans Inflammation / metabolism* Insulin Resistance / physiology Intercellular Signaling Peptides and Proteins / metabolism* Mitochondria / metabolism Obesity / complications, physiopathology Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Adipokines; 0/Hormones; 0/Intercellular Signaling Peptides and Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fat: a matter of disturbance for the immune system.
Next Document: Noninvasive investigations for non alcoholic fatty liver disease and liver fibrosis.