Document Detail

Hepatic and serum bile acid compositions in patients with biliary atresia: a microanalysis using gas chromatography-mass spectrometry with negative ion chemical ionization detection.
MedLine Citation:
PMID:  9865469     Owner:  NLM     Status:  MEDLINE    
Hepatic and serum bile acids in five patients with biliary atresia were preoperatively determined by microanalysis using gas chromatography-mass spectrometry with negative ion chemical ionization detection. The hepatic content of total bile acids was markedly elevated (3079+/-711 nmol/g protein), most of which were primary bile acids. Accumulation of unconjugated bile acids (2.93% to 4.62% of the total) was observed in the liver tissue of these patients, although only trace amounts were detected in their sera. The ratio of glycine-conjugated to taurine-conjugated bile acids was 0.44+/-0.18 in liver tissue and 0.79+/-0.52 in serum and these values were significantly lower than those of controls. This study has shown that the composition of bile acids in serum does not reflect that in liver tissue faithfully. The accumulation of these hydrophobic bile acids may contribute to initiating or exacerbating liver injury in infants with cholestatic liver diseases.
D Abukawa; M Nakagawa; K Iinuma; M Nio; R Ohi; J Goto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  185     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1999-03-05     Completed Date:  1999-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  227-37     Citation Subset:  IM    
Department of Pediatrics, Tohoku University School of Medicine, Sendai.
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MeSH Terms
Bile Acids and Salts / analysis*,  blood
Biliary Atresia / blood,  metabolism*
Gas Chromatography-Mass Spectrometry / methods*
Liver / chemistry*
Reg. No./Substance:
0/Bile Acids and Salts; 0/Ions

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