| Hepatic rhabdomyosarcoma in an adult: a rare primary malignant liver tumor. Case report and literature review. | |
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MedLine Citation:
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PMID: 22319971 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Rhabdomyosarcomas are malignant tumors that display features of striated muscle differentiation. They are the most common soft-tissue sarcomas among children and young adults. In mature adults however there are very rare. The liver as a primary site in adults has only been described in 12 cases. We report a case of a primary alveolar rhabdomyosarcoma of the liver in a 59 year old female, confirmed by histological examination using immunohistochemical analysis (positive actin, desmin, vimentin and myogenin staining) and fluorescent in situ hybridization (FISH) analysis (positivity for PAX3/FOXO1A fusion). The patient underwent primary surgical resection, but presented a few weeks after surgery already with recurrent disease in the abdomen and bone metastasis. Despite initial good response to chemotherapy (doxorubicin/ifosfamide) and stable disease at 12 months after diagnosis, the patient died 31 months after the first presentation secondary to complicated abundant abdominal recurrent disease. We further present a review of the literature on published similar cases since 1979. |
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Authors:
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G Schoofs; L Braeye; R Vanheste; G Verswijvel; M Debiec-Rychter; R Sciot |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta gastro-enterologica Belgica Volume: 74 ISSN: 0001-5644 ISO Abbreviation: Acta Gastroenterol. Belg. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0414075 Medline TA: Acta Gastroenterol Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 576-81 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, University Hospital Leuven, Belgium. goeleschoofs@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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