| Hepatic resection and transplantation for primary carcinoid tumors of the liver. | |
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MedLine Citation:
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PMID: 14745329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To discuss the diagnosis and management of primary carcinoid tumors of the liver in light of our experience and a literature review. SUMMARY BACKGROUND DATA: Carcinoid tumors of the liver are rare and pose a diagnostic and management dilemma. This series is the largest reported and the only one to include liver transplantation as a treatment option. METHODS: Between March 1994 and May 2002, we treated 8 patients (4 male, 4 female) with primary hepatic carcinoid tumors. Carcinoid syndrome complicated only 1 of the cases. Treatment was by liver resection in 6 patients and orthotopic liver transplantation in 2. RESULTS: The diagnosis was confirmed histologically with light microscopy and immunohistochemistry in the absence of an alternative primary site. Six patients remain alive and disease free after follow-up of more than 3 years: 39, 43, 45, 50, 50, and 95 months. Two patients are recently postoperative. CONCLUSIONS: Active exclusion of an extrahepatic primary site is essential for the diagnosis of primary carcinoid of the liver. The mainstay of treatment should be liver resection, although liver transplantation may be considered in patients with widespread hepatic involvement. A radical surgical approach is warranted as this disease carries a better prognosis than for other primary hepatic tumors and for secondary hepatic carcinoids. |
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Authors:
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Stephen W Fenwick; Judith I Wyatt; Giles J Toogood; J Peter A Lodge |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Annals of surgery Volume: 239 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-01-27 Completed Date: 2004-02-18 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: United States |
Other Details:
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Languages: eng Pagination: 210-9 Citation Subset: AIM; IM |
Affiliation:
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Hepatobiliary and Transplant Unit, St James's University Hospital, Leeds, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoid Tumor / diagnosis, surgery* Female Hepatectomy* Humans Liver Neoplasms / diagnosis, surgery* Liver Transplantation* Male Middle Aged |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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