Document Detail


Hepatic and renal effects of low concentrations of methoxyflurane in exposed delivery ward personnel.
MedLine Citation:
PMID:  7218059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During five alternating three-week periods either methoxyflurane-nitrous oxide or nitrous oxide alone was used for obstetrical analgesia. Delivery ward personnel were followed by venous blood samples once a week. Analyses of blood urea nitrogen, serum uric acid, SGOT and SGPT showed significantly elevated levels three days after exposure to methoxyflurane. This study demonstrates the importance of the scavenging of anesthetic gases to reduce the exposure of personnel to inhalational agents used in delivery suites. Since definite alterations in the indices of both hepatic and renal functions were recognized in obstetrical personnel following exposure, a re-evaluation of the use of methoxyflurane for obstetrical analgesia is suggested.
Authors:
B E Dahlgren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of occupational medicine. : official publication of the Industrial Medical Association     Volume:  22     ISSN:  0096-1736     ISO Abbreviation:  J Occup Med     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7502807     Medline TA:  J Occup Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  817-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Blood Urea Nitrogen
Drug-Induced Liver Injury*
Environmental Exposure
Humans
Kidney Diseases / chemically induced*
Methoxyflurane / adverse effects*
Obstetrics and Gynecology Department, Hospital
Personnel, Hospital*
Time Factors
Uric Acid / blood
Chemical
Reg. No./Substance:
69-93-2/Uric Acid; 76-38-0/Methoxyflurane; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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