| Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome. | |
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MedLine Citation:
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PMID: 19353590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Oxaliplatin is a chemotherapeutic drug for colorectal adenocarcinoma able to extend the indications for resection of colorectal liver metastases. However, the drug may severely injure hepatic sinusoids, inducing a sinusoidal obstruction syndrome in non-tumoral parenchyma with a risk of decreased regeneration in the remnant liver following partial hepatectomy. METHODS: We then investigated the evolution of hepatic functions and liver regeneration following partial hepatectomy in rats with sinusoidal obstruction syndrome. The sinusoidal obstruction syndrome was induced with a single intragastric administration of monocrotaline (MCT). RESULTS: MCT administration induced obstruction of the hepatic microcirculation and increased portal pressure, hepatic VEGF expression, and Ki67 positive hepatocytes. A mild cholestasis was present without modification of hepatic tests. Following a 70% hepatectomy, liver regeneration was significantly impaired by MCT administration and this impaired regeneration was associated with hepatocellular injury evidenced 1 week after hepatectomy. CONCLUSIONS: The presence of sinusoidal obstruction syndrome impairs hepatic regeneration in this rat model of sinusoidal obstruction syndrome. |
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Authors:
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Eduardo Schiffer; Jean-Louis Frossard; Laura Rubbia-Brandt; Gilles Mentha; Catherine M Pastor |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of surgical oncology Volume: 99 ISSN: 1096-9098 ISO Abbreviation: J Surg Oncol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-11 Completed Date: 2009-05-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0222643 Medline TA: J Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 439-46 Citation Subset: IM |
Affiliation:
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Laboratoire de Physiopathologie Hépatique et Imagerie Moléculaire, Hôpitaux Universitaires de Genève, Geneva 1205, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / adverse effects* Colorectal Neoplasms / drug therapy Disease Models, Animal Hepatectomy Hepatic Veno-Occlusive Disease / chemically induced, physiopathology*, surgery Liver Regeneration* Monocrotaline Organoplatinum Compounds / adverse effects Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Organoplatinum Compounds; 315-22-0/Monocrotaline; 63121-00-6/oxaliplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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