Document Detail

Hepatic-portal oleic acid inhibits feeding more potently than hepatic-portal caprylic acid in rats.
MedLine Citation:
PMID:  16890966     Owner:  NLM     Status:  MEDLINE    
In several human and animal studies, medium-chain triglycerides decreased food intake more than did long-chain triglycerides. It is possible that faster uptake and metabolism of medium-chain fatty acids in the liver is responsible for this difference. To test this hypothesis we compared the feeding effects of hepatic portal vein (HPV) infusion of the medium-chain fatty acid caprylic acid (CA) with those of the long-chain fatty acid oleic acid (OA). Contrary to our expectation, six-h HPV infusion of 14 microg/min (50 nmol/min) OA robustly inhibited feeding, whereas infusion of 22 or 220 microg/min (150 and 1500 nmol/min) CA failed to have any effect on feeding. Only a much larger dose of CA, 1100 microg/min (7500 nmol/min) inhibited feeding similarly to 14 microg/min OA. The increased feeding-inhibitory potency of OA did not appear to be due to differences in stimulation of hepatic fatty acid oxidation because equimolar (50 nmol/min) doses of OA (14 microg/min) and CA (7 microg/min) did not differentially affect post-infusion levels of beta-hydroxybutyrate. Stress, inflammation, acute hepatotoxicity or oxidative stress also do not appear to account for the increased feeding-inhibitory potency of HPV OA because plasma concentrations of the stress hormones corticosterone and epinephrine, the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, the liver enzymes gamma-glutamyl transferase and alanine aminotransferase and as well as hepatic levels of malondialdehyde and glutathione were all similar after HPV infusion of saline or of 50 nmol/min OA or CA.
Ulrike L Jambor de Sousa; Lambertus Benthem; Denis Arsenijevic; Anton J W Scheurink; Wolfgang Langhans; Nori Geary; Monika Leonhardt
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2006-08-07
Journal Detail:
Title:  Physiology & behavior     Volume:  89     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2006-12-12     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
Institute of Animal Sciences, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland.
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MeSH Terms
Appetite Depressants / administration & dosage*
Behavior, Animal
Dose-Response Relationship, Drug
Drug Administration Routes
Eating / drug effects*,  physiology
Glutathione / metabolism
Malondialdehyde / metabolism
Octanoic Acids / administration & dosage*
Oleic Acid / administration & dosage*
Portal Vein / drug effects*
Rats, Sprague-Dawley
Time Factors
Grant Support
Reg. No./Substance:
0/Appetite Depressants; 0/Octanoic Acids; 112-80-1/Oleic Acid; 124-07-2/caprylic acid; 542-78-9/Malondialdehyde; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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