| Hepatic-portal oleic acid inhibits feeding more potently than hepatic-portal caprylic acid in rats. | |
| | |
MedLine Citation:
|
PMID: 16890966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In several human and animal studies, medium-chain triglycerides decreased food intake more than did long-chain triglycerides. It is possible that faster uptake and metabolism of medium-chain fatty acids in the liver is responsible for this difference. To test this hypothesis we compared the feeding effects of hepatic portal vein (HPV) infusion of the medium-chain fatty acid caprylic acid (CA) with those of the long-chain fatty acid oleic acid (OA). Contrary to our expectation, six-h HPV infusion of 14 microg/min (50 nmol/min) OA robustly inhibited feeding, whereas infusion of 22 or 220 microg/min (150 and 1500 nmol/min) CA failed to have any effect on feeding. Only a much larger dose of CA, 1100 microg/min (7500 nmol/min) inhibited feeding similarly to 14 microg/min OA. The increased feeding-inhibitory potency of OA did not appear to be due to differences in stimulation of hepatic fatty acid oxidation because equimolar (50 nmol/min) doses of OA (14 microg/min) and CA (7 microg/min) did not differentially affect post-infusion levels of beta-hydroxybutyrate. Stress, inflammation, acute hepatotoxicity or oxidative stress also do not appear to account for the increased feeding-inhibitory potency of HPV OA because plasma concentrations of the stress hormones corticosterone and epinephrine, the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, the liver enzymes gamma-glutamyl transferase and alanine aminotransferase and as well as hepatic levels of malondialdehyde and glutathione were all similar after HPV infusion of saline or of 50 nmol/min OA or CA. |
| | |
Authors:
|
Ulrike L Jambor de Sousa; Lambertus Benthem; Denis Arsenijevic; Anton J W Scheurink; Wolfgang Langhans; Nori Geary; Monika Leonhardt |
Related Documents
:
|
15530016 - Effect of short-chain acids on the carboxymethylcellulase activity of the ruminal bacte... 3110446 - Studies on the tolerance of medium chain triglycerides in dogs. 6704136 - Antimitochondrial effect of saturated medium chain length (c8-c13) dicarboxylic acids. 4561406 - Defective deoxyribonucleic acid replication of t4rii bacteriophage in lambda-lysogenic ... 2912746 - The convulsant effects of kainic acid microinjections into cerebral cortex are concentr... 6526896 - Analysis of phospholipids in cow's milk by high-temperature injection gas chromatograph... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2006-08-07 |
Journal Detail:
|
Title: Physiology & behavior Volume: 89 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-10-02 Completed Date: 2006-12-12 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
|
Languages: eng Pagination: 329-34 Citation Subset: IM |
Affiliation:
|
Institute of Animal Sciences, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Appetite Depressants / administration & dosage* Behavior, Animal Dose-Response Relationship, Drug Drug Administration Routes Eating / drug effects*, physiology Glutathione / metabolism Liver* Male Malondialdehyde / metabolism Octanoic Acids / administration & dosage* Oleic Acid / administration & dosage* Portal Vein / drug effects* Rats Rats, Sprague-Dawley Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
DK 060735/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Appetite Depressants; 0/Octanoic Acids; 112-80-1/Oleic Acid; 124-07-2/caprylic acid; 542-78-9/Malondialdehyde; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Constitutive endocytosis of the metabotropic glutamate receptor mGluR7 is clathrin-independent.
Next Document: Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officina...