| Hepatic perfusion changes in an experimental model of acute pancreatitis: evaluation by perfusion CT. | |
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MedLine Citation:
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PMID: 19501998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: It is known that acute pancreatitis may cause secondary changes in several organs. Liver is one of these involved organs. In different experimental studies hepatic damages were shown histopathologically in acute pancreatitis but there are a few studies about perfusion disorders that accompany these histopathologic changes. Perfusion CT (pCT) provides the ability to detect regional and global alterations in organ blood flow. The purpose of the study was to describe hepatic perfusion changes in experimental acute pancreatitis model with pCT. MATERIALS AND METHODS: Forty Sprague-Dawley rats of both genders with average weights of 250 g were used. Rats were randomized into two groups. Twenty rats were in control group and 20 in acute pancreatitis group. pCT was performed. Perfusion maps were formed by processing the obtained images with perfusion CT software. Blood flow (BF) and blood volume (BV) values were obtained from these maps. All pancreatic and liver tissues were taken off with laparotomy and histopathologic investigation was performed. Student's t test was used for statistical analyses. RESULTS: In pCT we found statistically significant increase in blood volume in both lobes of liver and in blood flow in right lobe of the liver (p<0.01). Although blood flow in left lobe of the liver increased, it did not reach statistical significance. CONCLUSION: The quantitative analysis of liver parenchyma with pCT showed that acute pancreatitis causes a significant perfusion changes in the hepatic tissue. Systemic mediators seem to be effective as well as local inflammatory changes in perfusion changes. |
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Authors:
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Semra Tutcu; Selim Serter; Yavuz Kaya; Eray Kara; Nalan Neşe; Gökhan Pekindil; Teoman Coşkun |
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Publication Detail:
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Type: Journal Article Date: 2009-06-06 |
Journal Detail:
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Title: European journal of radiology Volume: 75 ISSN: 1872-7727 ISO Abbreviation: Eur J Radiol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-13 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 203-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Surgery, Celal Bayar University, School of Medicine, Manisa, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Blood Volume Liver / blood supply*, radiography Pancreatitis / physiopathology*, radiography Perfusion Imaging Rats Rats, Sprague-Dawley Regional Blood Flow Tomography, X-Ray Computed* |
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