| Hepatic and pancreatic involvement in hereditary hemorrhagic telangiectasia: quantitative and qualitative evaluation with 64-section CT in asymptomatic adult patients. | |
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MedLine Citation:
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PMID: 21861188 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To analyse quantitatively and qualitatively asymptomatic hepatic and pancreatic involvement in hereditary haemorrhagic telangiectasia (HHT) using 64-section helical CT. MATERIALS AND METHODS: The 64-section helical CT examinations of 19 patients with HHT (8 men, 11 women; mean age, 58.6 years) were quantitatively and qualitatively analysed and compared to those of 19 control subjects who were matched for age and sex. Comparisons were made using univariate analysis. RESULTS: Dilated and tortuous intrahepatic arterial branches was the most discriminating independent variable (P < 0.0001) and had the highest specificity (100%; 19/19; 95%CI: 82%-100%) and accuracy (97%; 37/38; 95%CI: 86%-100%) for the diagnosis of HHT. Heterogeneous enhancement of hepatic parenchyma, intrahepatic telangiectases, hepatic artery to hepatic vein shunting, hepatic artery enlargement (i.e. diameter > 6.5 mm) and portal vein enlargement (i.e. diameter > 13 mm) were other variables that strongly correlated with the presence of HHT. Intrapancreatic telangiectases and arteriovenous malformations were found in 42% and 16% of patients with HHT, respectively. CONCLUSION: Liver and pancreatic involvement in asymptomatic HHT patients is associated with myriad suggestive findings on 64-section helical CT. It can be anticipated that familiarity with these findings would result in more confident diagnosis of HHT. Key Points • HHT hepatic and pancreatic involvement is associated with myriad findings shown by CT. • 64-section helical CT depicts hepatic and pancreatic involvement in asymptomatic HHT patients • Multidetector CT shows discriminating intrahepatic abnormalities for the diagnosis of HHT • CT heightens confidence in diagnosing hereditary haemorrhagic telangiectasia in equivocal cases. |
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Authors:
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Matthias Barral; Marc Sirol; Vinciane Placé; Lounis Hamzi; Michel Borsik; Etienne Gayat; Mourad Boudiaf; Philippe Soyer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-23 |
Journal Detail:
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Title: European radiology Volume: - ISSN: 1432-1084 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Abdominal Imaging, Hôpital Lariboisière-APHP, 2 rue Ambroise Paré, 75475, Paris cedex 10, France, matthias_barral@yahoo.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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