Document Detail

Hepatic non-parenchymal cells and extracellular matrix participate in oval cell-mediated liver regeneration.
MedLine Citation:
PMID:  19195056     Owner:  NLM     Status:  MEDLINE    
AIM: To elucidate the interaction between non-parenchymal cells, extracellular matrix and oval cells during the restituting process of liver injury induced by partial hepatectomy (PH).
METHODS: We examined the localization of oval cells, non-parenchymal cells, and the extracellular matrix components using immunohistochemical and double immunofluorescent analysis during the proliferation and differentiation of oval cells in N-2-acetylaminofluorene (2-AAF)/PH rat model.
RESULTS: By day 2 after PH, small oval cells began to proliferate around the portal area. Most of stellate cells and laminin were present along the hepatic sinusoids in the periportal area. Kupffer cells and fibronectin markedly increased in the whole hepatic lobule. From day 4 to 9, oval cells spread further into hepatic parenchyma, closely associated with stellate cells, fibronectin and laminin. Kupffer cells admixed with oval cells by day 6 and then decreased in the periportal zone. From day 12 to 15, most of hepatic stellate cells (HSCs), laminin and fibronectin located around the small hepatocyte nodus, and minority of them appeared in the nodus. Kupffer cells were mainly limited in the pericentral sinusoids. After day 18, the normal liver lobule structures began to recover.
CONCLUSION: Local hepatic microenvironment may participate in the oval cell-mediated liver regeneration through the cell-cell and cell-matrix interactions.
Wei Zhang; Xiao-Ping Chen; Wan-Guang Zhang; Feng Zhang; Shuai Xiang; Han-Hua Dong; Lei Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  15     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-05     Completed Date:  2009-05-20     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  552-60     Citation Subset:  IM    
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MeSH Terms
2-Acetylaminofluorene / toxicity
Carcinogens / toxicity
Cell Differentiation / drug effects
Cell Division / drug effects
Extracellular Matrix / drug effects,  physiology*
Hepatocytes / drug effects,  pathology
Liver / cytology*,  drug effects,  physiology*
Liver Regeneration / physiology*
Models, Animal
Rats, Sprague-Dawley
Stem Cells / cytology,  drug effects
Reg. No./Substance:
0/Carcinogens; 9M98QLJ2DL/2-Acetylaminofluorene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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