Document Detail

Hepatic microvascular pressure during anaphylactic shock in anesthetized rats.
MedLine Citation:
PMID:  19573539     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Hepatic venoconstriction plays a significant role in anaphylactic hypotension in anesthetized rats. The purpose of this study is to determine whether the primary site of anaphylactic venoconstriction in the liver venous circulation occurs prior to or distal to the sinusoidal capillaries. We also determined whether the hepatic blood volume is increased during anaphylactic hypotension. METHODS: We measured, using a servo-null micropipette pressure-measuring system, the hepatic venular transmural pressure (P micro hv) at the liver surface of anesthetized rats sensitized with the antigen of ovalbumin (1 mg). We also measured the liver lobe thickness, using the ultrasonic crystal dimension measuring system. Anaphylactic hypotension was induced by an intravenous injection of 0.6 mg ovalbumin. RESULTS: When the antigen was injected, the systemic arterial pressure decreased profoundly from 118+/-9 to 45+/-4 mm Hg, which was accompanied by an increase in Ppv and P micro hv: P micro hv only transiently increased from 3.1+/-0.9 to 8.8+/-1.5 cm H(2)O at 1 min and then rapidly returned to the baseline within 2 min, when Ppv continued to increase and reached the peak of 36+/-7 cm H(2)O at 3.5 min after antigen. This greater increase in Ppv-to-P micro hv gradient than that in P micro hv-to-Pcv gradient after antigen indicated that the constriction of the portal veins and the sinusoids much predominates over that of the hepatic veins. Along with this hepatic pre- and sinusoidal constriction, the liver lobe thickness significantly decreased by 4% after antigen. CONCLUSION: Pre-sinusoidal constriction during anaphylactic shock in anaesthetized rats increased the portal venous pressure while the hepatic venular pressure only increased slightly and transiently. This predominant pre-sinusoidal constriction is accompanied by a decrease in liver volume.
Hiromichi Takano; Toshishige Shibamoto; Wei Zhang; Yasutaka Kurata; Hirohisa Toga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-30
Journal Detail:
Title:  Microvascular research     Volume:  78     ISSN:  1095-9319     ISO Abbreviation:  Microvasc. Res.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0165035     Medline TA:  Microvasc Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
Department of Physiology II, Kanazawa Medical University, Uchinada 920-0293, Japan.
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MeSH Terms
Anaphylaxis / chemically induced,  immunology,  physiopathology*
Antigens / adverse effects,  immunology
Blood Pressure / physiology*
Blood Volume / drug effects
Hepatic Veins / drug effects,  immunology
Hypotension / chemically induced,  immunology,  physiopathology*
Liver / blood supply*,  drug effects,  immunology
Liver Circulation / drug effects,  immunology
Organ Size / drug effects,  immunology
Ovalbumin / immunology,  pharmacology
Portal Pressure / drug effects
Portal Vein / drug effects,  immunology
Rats, Sprague-Dawley
Time Factors
Vasoconstriction / drug effects,  immunology
Veins / drug effects,  immunology
Venous Pressure / drug effects
Reg. No./Substance:
0/Antigens; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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