Document Detail

Hepatic microcirculation in Zucker fatty rats.
MedLine Citation:
PMID:  3799339     Owner:  NLM     Status:  MEDLINE    
We have developed a microscopic analyzing system for studying in vivo hepatic microcirculation, and measured the sinusoidal erythrocyte flow velocity simultaneously in the various sinusoids. With this system and organ reflectance spectrophotometry, the pathophysiological role of microcirculation and of energy metabolism in Zucker fatty rats were studied. The results were as follows: The erythrocyte flow velocity in the predominant sinusoids in the fatty rats was similar to that of the control rats, but the intersinusoidal erythrocyte flow was undetected in the fatty liver. Index of regional hepatic blood volume, regional hepatic blood flow and oxygen saturation of Hb decreased significantly in the fatty rats. The estimated in vivo oxygen consumption was not changed in the fatty liver. From these data, it is concluded that in Zucker fatty rats a marked fatty infiltration causes a decreased hepatic tissue blood flow and volume, but relatively homogeneous erythrocyte flow with an increased extraction of oxygen compensated the decreased vascular beds and maintained normal energy metabolism.
N Sato; H Eguchi; A Inoue; T Matsumura; S Kawano; T Kamada
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  200     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-04     Completed Date:  1987-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  477-83     Citation Subset:  IM    
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MeSH Terms
Fatty Liver / physiopathology
Hemoglobins / analysis
Liver / metabolism
Liver Circulation*
Microcirculation / physiology,  physiopathology
Oxygen Consumption
Rats, Inbred Strains
Rats, Mutant Strains / physiology*
Rats, Zucker / physiology*
Species Specificity
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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