Document Detail

Hepatic metastatic thymoma and myasthenia gravis twenty-two years after the apparent cure of an invasive thymoma. A case report and review of the literature.
MedLine Citation:
PMID:  3537213     Owner:  NLM     Status:  MEDLINE    
We report the case of a 62-year-old woman who presented in myasthenic crisis 22 years after radiation- and chemotherapy of an invasive thymoma which occurred during pregnancy. There was no evidence of recurrence of the thymoma at its original site, but an isolated hepatic metastasis was discovered. Biopsy of the mass revealed a spindle cell thymoma, whereas the original histology was that of a mixed round and spindle cell thymoma with moderate lymphocytic infiltration. The patient expired in spite of treatment with steroids, pyridostigmine bromide and plasma exchange on the one hand and cyclophosphamide with adriamycin on the other. To our knowledge, 22 years is the longest reported interval for the appearance of metastatic thymoma and myasthenia gravis after the diagnosis and apparent cure of a primary thymoma. This is also the only reported case of thymoma occurring during pregnancy but not associated with a rapidly fatal outcome.
M A Denayer; K R Rao; D Wirz; D McNally
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  76     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-01-14     Completed Date:  1987-01-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
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MeSH Terms
Liver Neoplasms / complications,  pathology,  secondary*
Middle Aged
Myasthenia Gravis / complications*
Pregnancy Complications, Neoplastic / pathology
Thymoma / complications,  pathology,  secondary*
Thymus Neoplasms / complications*
Time Factors

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