Document Detail


Hepatic metastatic thymoma and myasthenia gravis twenty-two years after the apparent cure of an invasive thymoma. A case report and review of the literature.
MedLine Citation:
PMID:  3537213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the case of a 62-year-old woman who presented in myasthenic crisis 22 years after radiation- and chemotherapy of an invasive thymoma which occurred during pregnancy. There was no evidence of recurrence of the thymoma at its original site, but an isolated hepatic metastasis was discovered. Biopsy of the mass revealed a spindle cell thymoma, whereas the original histology was that of a mixed round and spindle cell thymoma with moderate lymphocytic infiltration. The patient expired in spite of treatment with steroids, pyridostigmine bromide and plasma exchange on the one hand and cyclophosphamide with adriamycin on the other. To our knowledge, 22 years is the longest reported interval for the appearance of metastatic thymoma and myasthenia gravis after the diagnosis and apparent cure of a primary thymoma. This is also the only reported case of thymoma occurring during pregnancy but not associated with a rapidly fatal outcome.
Authors:
M A Denayer; K R Rao; D Wirz; D McNally
Related Documents :
11549933 - Coexistence of delusions of pregnancy and infestation in a male.
16246423 - Legionella pneumophila pneumonia during pregnancy: a case report.
9191073 - Differential proopiomelanocortin gene expression in the medial basal hypothalamus of ra...
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  76     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-01-14     Completed Date:  1987-01-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Female
Humans
Liver Neoplasms / complications,  pathology,  secondary*
Middle Aged
Myasthenia Gravis / complications*
Pregnancy
Pregnancy Complications, Neoplastic / pathology
Thymoma / complications,  pathology,  secondary*
Thymus Neoplasms / complications*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Problems arising during chronic treatment with L-dopa for Parkinson's disease: changes in response t...
Next Document:  Twice-daily nicardipine in the treatment of essential hypertension.