| Hepatic metastases: in vivo assessment of perfusion parameters at dynamic contrast-enhanced MR imaging with dual-input two-compartment tracer kinetics model. | |
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MedLine Citation:
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PMID: 18695207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was institutional review board approved, with waived patient consent for retrospective analysis of the data. The hepatic perfusion at dynamic contrast material-enhanced magnetic resonance (MR) imaging was commonly described and assessed by using a dual-input one-compartment tracer kinetics model. Although the tracer kinetics in normal liver parenchyma can be described by using a single compartment, functional changes in the tumor microenvironment can result in distinctly different tracer behavior that entails a second tissue compartment. A dual-input two-compartment model is proposed to describe the tracer behavior in hepatic metastases. The authors applied this model to the dynamic MR imaging data obtained in three patients. Perfusion parameter maps and region-of-interest analysis revealed that tracer behavior in hepatic metastases-in contrast to that in surrounding normal liver tissue, which effectively involves one compartment-can be described by using two compartments. |
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Authors:
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Tong San Koh; Choon Hua Thng; Puor Sherng Lee; Septian Hartono; Helmut Rumpel; Boon Cher Goh; Sotirios Bisdas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-11 |
Journal Detail:
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Title: Radiology Volume: 249 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-17 Completed Date: 2008-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 307-20 Citation Subset: AIM; IM |
Copyright Information:
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(c) RSNA, 2008. |
Affiliation:
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School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Liver Neoplasms / blood supply*, secondary* Magnetic Resonance Imaging / methods* Middle Aged Models, Theoretical Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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